ArticleGenes & development2000
members only encodes a Drosophila nucleoporin required for rel protein import and immune response activation.
Article in Genes & development, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 2 citations in OpenAlex.
- Article
- Cell-Mediated Branch Fusion in the Drosophila Trachea.Results and problems in cell differentiation · 2024Review
- Overexpressed Nup88 stabilized through interaction with Nup62 promotes NF-κB dependent pathways in cancer.Frontiers in oncology · 2023Article
- Expression and Function of Toll Pathway Components in the Early Development of the WaspJournal of developmental biology · 2022Article
- Nuclear pore complexes in development and tissue homeostasis.Development (Cambridge, England) · 2020Review
- Complex Genetic Architecture Underlies Regulation of Influenza-A-Virus-Specific Antibody Responses in the Collaborative Cross.Cell reports · 2020Article
- Article
- A critical role for nucleoporin 358 (Nup358) in transposon silencing and piRNA biogenesis inThe Journal of biological chemistry · 2018Article
- Article
- Functional insights of nucleocytoplasmic transport in plants.Frontiers in plant science · 2014Review
- Nuclear pore complex composition: a new regulator of tissue-specific and developmental functions.Nature reviews. Molecular cell biology · 2012Review
- The nucleoporin Nup88 is interacting with nuclear lamin A.Molecular biology of the cell · 2011Article
- Nucleo-cytoplasmic transport of proteins and RNA in plants.Plant cell reports · 2011Review
- A nuclear targeting system in Plasmodium falciparum.Malaria journal · 2010Article
- Flexible gates: dynamic topologies and functions for FG nucleoporins in nucleocytoplasmic transport.Eukaryotic cell · 2009Review
- Nuclear pore complex component MOS7/Nup88 is required for innate immunity and nuclear accumulation of defense regulators in Arabidopsis.The Plant cell · 2009Article
- The role of nuclear pores in gene regulation, development and disease.EMBO reports · 2009Review
- Nuclear pore proteins and cancer.Seminars in cell & developmental biology · 2009Review
- How do kidney cells adapt to survive in hypertonic inner medulla?Transactions of the American Clinical and Climatological Association · 2009Review
- Nucleoporin 88 (Nup88) is regulated by hypertonic stress in kidney cells to retain the transcription factor tonicity enhancer-binding protein (TonEBP) in the nucleus.The Journal of biological chemistry · 2008Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many developmental and physiological responses rely on the selective translocation of transcriptional regulators in and out of the nucleus through the nuclear pores. Here we describe the Drosophila gene members only (mbo) encoding a nucleoporin homologous to the mammalian Nup88. The phenotypes of mbo mutants and mbo expression during development are cell specific, indicating that the nuclear import capacity of cells is differentially regulated. Using inducible assays for nucleocytoplasmic trafficking we show that mRNA export and classic NLS-mediated protein import are unaffected in mbo mutants. Instead, mbo is selectively required for the nuclear import of the yeast transcription factor GAL4 in a subset of the larval tissues. We have identified the first endogenous targets of the mbo nuclear import pathway in the Rel proteins Dorsal and Dif. In mbo mutants the upstream signaling events leading to the degradation of the IkappaB homolog Cactus are functional, but Dorsal and Dif remain cytoplasmic and the larval immune response is not activated in response to infection. Our results demonstrate that distinct nuclear import events require different nucleoporins in vivo and suggest a regulatory role for mbo in signal transduction.
Indexed as
Identifiers
10921908PMC316830W1500462494What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.