ArticleGenes & development2000
A C. elegans patched gene, ptc-1, functions in germ-line cytokinesis.
Article in Genes & development, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
38 citing papers in PubMed, 103 citations in OpenAlex.
- Early life starvation and Hedgehog-related signaling activate innate immunity downstream of daf-18/PTEN and lin-35/Rb causing developmental pathology in adult C. elegans.PLoS genetics · 2025Article
- Stage-specific exposure of Caenorhabditis elegans to cadmium identifies unique transcriptomic response cascades and an uncharacterized cadmium responsive transcript.Metallomics : integrated biometal science · 2024Article
- Reevaluation of the role of LIP-1 as an ERK/MPK-1 dual specificity phosphatase in theProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Functional Analysis of the C-5 Sterol Desaturase PcErg3 in the Sterol Auxotrophic Oomycete PathogenFrontiers in microbiology · 2022Article
- Meta-Analysis ofFrontiers in microbiology · 2022Article
- Patched-Related Is Required for Proper Development of EmbryonicFrontiers in neuroscience · 2022Article
- Patched regulates lipid homeostasis by controlling cellular cholesterol levels.Nature communications · 2021Article
- Caenorhabditis elegans PTR/PTCHD PTR-18 promotes the clearance of extracellular hedgehog-related protein via endocytosis.PLoS genetics · 2021Article
- A Patched-Like Protein PsPTL Is Not Essential for the Growth and Response to Various Stresses inFrontiers in microbiology · 2021Article
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- CREB Non-autonomously Controls Reproductive Aging through Hedgehog/Patched Signaling.Developmental cell · 2020Article
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- How Weird is The Worm? Evolution of the Developmental Gene Toolkit inJournal of developmental biology · 2019Review
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- Functional Interactions BetweenG3 (Bethesda, Md.) · 2018Article
- Actomyosin contractility regulators stabilize the cytoplasmic bridge between the two primordial germ cells duringMolecular biology of the cell · 2017Article
- Molting inWorm · 2017Review
- Probing extracellular Sonic hedgehog in neurons.Biology open · 2016Article
- PHA-4/FOXA-regulated microRNA feed forward loops during Caenorhabditis elegans dietary restriction.Aging · 2014Article
- Some, but not all, retromer components promote morphogenesis of C. elegans sensory compartments.Developmental biology · 2012Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Patched (Ptc), initially identified in Drosophila, defines a class of multipass membrane proteins that control cell fate and cell proliferation. Biochemical studies in vertebrates indicate that the membrane proteins Ptc and Smoothened (Smo) form a receptor complex that binds Hedgehog (Hh) morphogens. Smo transduces the Hh signal to downstream effectors. The Caenorhabditis elegans genome encodes two Ptc homologs and one related pseudogene but does not encode obvious Hh or Smo homologs. We have analyzed ptc-1 by RNAi and mutational deletion and find that it is an essential gene, although the absence of ptc-1 has no detectable effect on body patterning or proliferation. Therefore, the C. elegans ptc-1 gene is functional despite the lack of Hh and Smo homologs. We find that the activity and expression of ptc-1 is essentially confined to the germ line and its progenitors. ptc-1 null mutants are sterile with multinucleate germ cells arising from a probable cytokinesis defect. We have also identified a surprisingly large family of PTC-related proteins containing sterol-sensing domains, including homologs of Drosophila dispatched, in C. elegans and other phyla. These results suggest that the PTC superfamily has multiple functions in animal development.
Indexed as
Identifiers
10921907PMC316821W1835931275What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.