ArticleThe EMBO journal2000
Derepression of DNA damage-regulated genes requires yeast TAF(II)s.
Article in The EMBO journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Phosphoproteomic analysis of protein kinase C signaling in Saccharomyces cerevisiae reveals Slt2 mitogen-activated protein kinase (MAPK)-dependent phosphorylation of eisosome core components.Molecular & cellular proteomics : MCP · 2013Article
- Article
- Dissection of coactivator requirement at RNR3 reveals unexpected contributions from TFIID and SAGA.The Journal of biological chemistry · 2008Article
- Yeast Rap1 contributes to genomic integrity by activating DNA damage repair genes.The EMBO journal · 2008Article
- Selective requirement for SAGA in Hog1-mediated gene expression depending on the severity of the external osmostress conditions.Molecular and cellular biology · 2007Article
- Exposing the core promoter is sufficient to activate transcription and alter coactivator requirement at RNR3.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- INO80 subfamily of chromatin remodeling complexes.Mutation research · 2007Review
- Histone deacetylases RPD3 and HOS2 regulate the transcriptional activation of DNA damage-inducible genes.Molecular and cellular biology · 2007Article
- Molecular genetic analysis of the yeast repressor Rfx1/Crt1 reveals a novel two-step regulatory mechanism.Molecular and cellular biology · 2005Article
- DNA damage and replication stress induced transcription of RNR genes is dependent on the Ccr4-Not complex.Nucleic acids research · 2005Article
- Global role of TATA box-binding protein recruitment to promoters in mediating gene expression profiles.Molecular and cellular biology · 2004Article
- UV-C response of the ribonucleotide reductase large subunit involves both E2F-mediated gene transcriptional regulation and protein subcellular relocalization in tobacco cells.Nucleic acids research · 2004Article
- Systematic analysis of essential yeast TAFs in genome-wide transcription and preinitiation complex assembly.The EMBO journal · 2003Article
- SWI/SNF-dependent chromatin remodeling of RNR3 requires TAF(II)s and the general transcription machinery.Genes & development · 2003Article
- Protein-protein interaction map for yeast TFIID.Nucleic acids research · 2003Article
- Rhodobacter sphaeroides LexA has dual activity: optimising and repressing recA gene transcription.Nucleic acids research · 2002Article
- Analysis of TAF90 mutants displaying allele-specific and broad defects in transcription.Molecular and cellular biology · 2001Article
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2 authors at 1 institution in 1 country.
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Abstract
The general transcription factor TFIID and its individual subunits (TAF(II)s) have been the focus of many studies, yet their functions in vivo are not well established. Here we characterize the requirement of yeast TAF(II)s for the derepression of the ribonucleotide reductase (RNR) genes. Promoter mapping studies revealed that the upstream repressing sequences, the damage-responsive elements (DREs), rendered these genes dependent upon TAF(II)s. DREs are the binding sites for the sequence-specific DNA binding-protein Crt1 that represses transcription by recruiting the Ssn6-Tup1 co-repressor complex to the promoter. We demonstrate that deletion of SSN6, TUP1 or CRT1 alleviated the TAF(II) dependence of the RNR genes, indicating that TAF(II) dependence requires the co-repressor complex. Furthermore, we provide evidence that Crt1 specifies the TAF(II) dependence of these genes. Our studies show that TFIID interacts with the repression domain of Crt1, suggesting that the derepression mechanism involves an antagonism between TFIID and the co-repressor complex. Our results indicate that yeast TAF(II)s have other functions in addition to core promoter selectivity, and describe a novel activity: the derepression of promoters.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.