ArticleThe EMBO journal2000
Fission yeast Fizzy-related protein srw1p is a G(1)-specific promoter of mitotic cyclin B degradation.
Article in The EMBO journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 59 citations in OpenAlex.
- Computational modeling of chromosome re-replication in mutant strains of fission yeast.Molecular biology of the cell · 2021Article
- CDK Regulation of Meiosis: Lessons fromGenes · 2020Review
- Suppression of APC/CCdh1 has subtype specific biological effects in acute myeloid leukemia.Oncotarget · 2016Article
- Mechanism of APC/CCDC20 activation by mitotic phosphorylation.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Genome-wide analysis of the cyclin gene family in tomato.International journal of molecular sciences · 2013Article
- Article
- Mathematical modeling of fission yeast Schizosaccharomyces pombe cell cycle: exploring the role of multiple phosphatases.Systems and synthetic biology · 2011Article
- Cdk5 phosphorylates Cdh1 and modulates cyclin B1 stability in excitotoxicity.The EMBO journal · 2008Article
- Article
- Regulation of APC/C activators in mitosis and meiosis.Annual review of cell and developmental biology · 2008Review
- Pathocycles: Ustilago maydis as a model to study the relationships between cell cycle and virulence in pathogenic fungi.Molecular genetics and genomics : MGG · 2006Review
- Cdh1/Hct1-APC is essential for the survival of postmitotic neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Identification of cell cycle-regulated genes in fission yeast.Molecular biology of the cell · 2005Article
- Differential expression, localization and activity of two alternatively spliced isoforms of human APC regulator CDH1.The Biochemical journal · 2003Article
- Two ubiquitin-conjugating enzymes, UbcP1/Ubc4 and UbcP4/Ubc11, have distinct functions for ubiquitination of mitotic cyclin.Molecular and cellular biology · 2003Article
- Developmental defects observed in hypomorphic anaphase-promoting complex mutants are linked to cell cycle abnormalities.Development (Cambridge, England) · 2003Article
- Function of Cdc2p-dependent Bub1p phosphorylation and Bub1p kinase activity in the mitotic and meiotic spindle checkpoint.The EMBO journal · 2003Article
- Yeast Hct1 recognizes the mitotic cyclin Clb2 and other substrates of the ubiquitin ligase APC.The EMBO journal · 2001Article
- A conserved cyclin-binding domain determines functional interplay between anaphase-promoting complex-Cdh1 and cyclin A-Cdk2 during cell cycle progression.Molecular and cellular biology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Downregulation of cyclin-dependent kinase (Cdk)-mitotic cyclin complexes is important during cell cycle progression and in G(1) arrested cells undergoing differentiation. srw1p, a member of the Fizzy-related protein family in fission yeast, is required for the degradation of cdc13p mitotic cyclin B during G(1) arrest. Here we show that srw1p is not required for the degradation of cdc13p during mitotic exit demonstrating that there are two systems operative at different stages of the cell cycle for cdc13p degradation, and that srw1p is phosphorylated by Cdk-cdc13p only becoming dephosphorylated during G(1) arrest. We propose that this phosphorylation targets srw1p for proteolysis and inhibits its activity to promote cdc13p turnover.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.