ReviewCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2000
Emerging relations between infectious diseases and coronary artery disease and atherosclerosis.
Review in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 4 syntheses or guidelines pooled it, 141 citations in OpenAlex.
- Cytomegalovirus infection and cardiovascular outcomes in abdominal organ transplant recipients: A systematic review and meta-analysis.Transplantation reviews (Orlando, Fla.) · 2024Pooled it
- A Comprehensive Survey of the Relationship betweenArchives of Iranian medicine · 2022Pooled it
- Cytomegalovirus infection and coronary heart disease risk: a meta-analysis.Molecular biology reports · 2012Pooled it
- Association of circulating Chlamydia pneumoniae DNA with cardiovascular disease: a systematic review.BMC infectious diseases · 2002Pooled it
- Persistence of an atherogenic lipid profile after treatment of acute infection with Brucella.Journal of lipid research · 2009Trial
- Memory inflation: Beyond the acute phase of viral infection.Cell proliferation · 2024Review
- Population-level impact of adverse early life conditions on adult healthy life expectancy in low- and middle-income countries.Population studies · 2022Article
- Coronary arteritis as a cause of sudden cardiac death in a young girl.Autopsy & case reports · 2021Review
- Social and population health science approaches to understand the human microbiome.Nature human behaviour · 2018Article
- Oral microbiome development during childhood: an ecological succession influenced by postnatal factors and associated with tooth decay.The ISME journal · 2018Article
- Latent tuberculosis infection among patients with erectile dysfunction.International journal of impotence research · 2018Article
- Discrete Barker Frailty and Warped Mortality Dynamics at Older Ages.Demography · 2017Article
- Impact of sepsis on risk of postoperative arterial and venous thromboses: large prospective cohort study.BMJ (Clinical research ed.) · 2014Article
- Increased prevalence of coronary artery disease risk markers in patients with chronic hepatitis C--a cross-sectional study.Vascular health and risk management · 2014Article
- The impact of the 2008 cold spell on mortality in Shanghai, China.International journal of biometeorology · 2013Article
- Atherosclerosis Induced by Chlamydophila pneumoniae: A Controversial Theory.Interdisciplinary perspectives on infectious diseases · 2013Article
- Is helicobacter pylori infection a risk factor for coronary heart disease?ARYA atherosclerosis · 2012Article
- Animal models for the atherosclerosis research: a review.Protein & cell · 2011Review
- Detection of human cytomegalovirus and epstein-barr virus in coronary atherosclerotic tissue.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2010Article
- Hepatitis C virus infection and the risk of coronary disease.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cardiovascular disease is the leading cause of death in developed countries. The cause is multifactorial. A substantial proportion of patients with coronary artery disease (CAD) do not have traditional risk factors. Infectious diseases may play a role in these cases, or they may intensify the effect of other risk factors. The association of CAD and Chlamydia pneumoniae infection is firmly established, but causality is yet to be proven. The link with other infectious agents or conditions, such as cytomegalovirus, herpes simplex virus, Helicobacter pylori and periodontitis, is more controversial. Cytomegalovirus infection is more strongly linked than native CAD to coronary artery restenosis after angioplasty and to accelerated CAD after cardiac transplantation. However, new data on this topic are appearing in the literature almost every month. The potential for novel therapeutic management of cardiovascular disease and stroke is great if infection is proven to cause or accelerate CAD or atherosclerosis. However, physicians should not "jump the gun" and start using antibiotic therapy prematurely for CAD. The results of large randomized clinical trials in progress will help establish causality and the benefits of antimicrobial therapy in CAD.
Indexed as
Identifiers
10920732PMC1232552W1939070268What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.