ArticleProceedings of the National Academy of Sciences of the United States of America2000
The human VASA gene is specifically expressed in the germ cell lineage.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 206 papers.
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206 citing papers in PubMed, 561 citations in OpenAlex.
- Conserved RNA helicase Vasa regulates ribonucleoprotein condensate dynamics and mRNA localization.iScience · 2026Article
- A Nanos3-containing protein complex can activate RNA translation in primordial germ cells in vivo.EMBO reports · 2026Article
- Sex-Specific Gene Expression Ontogeny During Gonadal Development in Post-Metamorphic Xenopus tropicalis.Molecular reproduction and development · 2026Article
- Testicular mRNA-LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Primordial germ cell-like cells residing in the pituitary may serve as the origin of intracranial germ cell tumors.Scientific reports · 2026Article
- Low-level lasers can improve spermatogenesis in infertile mice by targeting molecular pathways.BioImpacts : BI · 2026Article
- Conserved RNA helicase Vasa regulates ribonucleoprotein condensates through protein interaction and mRNA recruitment.bioRxiv : the preprint server for biology · 2025Article
- Identification, Isolation, and In Vitro Culture Trials of Ovarian Germ Stem Cells from Different Teleost Fish Species.Veterinary sciences · 2025Article
- Germline factors, TDRD and Piwi, colocalize with Vasa on the mitotic apparatus during the embryogenesis of the sea urchin.Developmental biology · 2025Article
- A comparison of spermatogenesis between flies and men-conserved processes of male gamete production.Human reproduction update · 2025Review
- Effect of Extracellular Matrix Derived from Porcine Tissue on Stemness of Porcine Spermatogonial Stem Cells.International journal of molecular sciences · 2025Article
- Germline stem cell isolation, lineage tracing, and aging in a protochordate.bioRxiv : the preprint server for biology · 2025Article
- Article
- Human sperm RNA in male infertility.Nature reviews. Urology · 2025Review
- The effect of Sertoli cell exosomes on spermatogonia stem cells differentiation.BioImpacts : BI · 2025Article
- Oocyte death is triggered by the stabilization of TAp63α dimers in response to cisplatin.Cell death & disease · 2024Article
- Characterization of potential spermatogonia biomarker genes in the European eel (Anguilla anguilla).Fish physiology and biochemistry · 2024Article
- Single-cell proteomics reveals decreased abundance of proteostasis and meiosis proteins in advanced maternal age oocytes.Molecular human reproduction · 2024Article
- Prenatal AAV9-GFP administration in fetal lambs results in transduction of female germ cells and maternal exposure to virus.Molecular therapy. Methods & clinical development · 2024Article
- Characteristics of theGenes · 2024Article
146 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To understand the origins and function of the human germ cell lineage and to identify germ cell-specific markers we have isolated a human ortholog of the Drosophila gene vasa. The gene was mapped to human chromosome 5q (near the centromere) by radiation hybrid mapping. We show by Northern analysis of fetal and adult tissues that expression of the human VASA gene is restricted to the ovary and testis and is undetectable in somatic tissues. We generated polyclonal antibodies that bind to the VASA protein in formalin-fixed, paraffin-embedded tissue and characterized VASA protein expression in human germ cells at various stages of development. The VASA protein is cytoplasmic and expressed in migratory primordial germ cells in the region of the gonadal ridge. VASA protein is present in fetal and adult gonadal germ cells in both males and females and is most abundant in spermatocytes and mature oocytes. The gene we have isolated is thus a highly specific marker of germ cells and should be useful for studies of human germ cell determination and function.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.