ArticleProceedings of the National Academy of Sciences of the United States of America2000
Autocatalytic proteolysis of the transcription factor-coactivator C1 (HCF): a potential role for proteolytic regulation of coactivator function.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Conformational preorganization of neighbouring groups modulates and expedites polymer self-deconstruction.Nature chemistry · 2026Article
- Article
- Proteolytic cleavage is required for functional neuroligin 2 maturation and trafficking in Drosophila.Journal of molecular cell biology · 2017Article
- The making of a sweet modification: structure and function of O-GlcNAc transferase.The Journal of biological chemistry · 2014Review
- Augmented generation of protein fragments during wakefulness as the molecular cause of sleep: a hypothesis.Protein science : a publication of the Protein Society · 2012Article
- Crosstalk between O-GlcNAcylation and proteolytic cleavage regulates the host cell factor-1 maturation pathway.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- PGC-1-related coactivator complexes with HCF-1 and NRF-2beta in mediating NRF-2(GABP)-dependent respiratory gene expression.The Journal of biological chemistry · 2008Article
- Species selectivity of mixed-lineage leukemia/trithorax and HCF proteolytic maturation pathways.Molecular and cellular biology · 2007Article
- Differential subcellular localization and activity of kelch repeat proteins KLHDC1 and KLHDC2.Molecular and cellular biochemistry · 2007Article
- Host cell factor-1 and E2F4 interact via multiple determinants in each protein.Molecular and cellular biochemistry · 2006Article
- Site-specific proteolysis of the transcriptional coactivator HCF-1 can regulate its interaction with protein cofactors.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Herpes simplex virus infections are arrested in Oct-1-deficient cells.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Proteolytic processing is necessary to separate and ensure proper cell growth and cytokinesis functions of HCF-1.The EMBO journal · 2003Article
- Molecular cloning of Drosophila HCF reveals proteolytic processing and self-association of the encoded protein.Journal of cellular physiology · 2003Article
- Interaction of HCF-1 with a cellular nuclear export factor.The Journal of biological chemistry · 2002Article
- PDCD2 is a negative regulator of HCF-1 (C1).Oncogene · 2002Article
- S phase-specific proteolytic cleavage is required to activate stable DNA binding by the CDP/Cut homeodomain protein.Molecular and cellular biology · 2001Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Site-specific proteolysis is an important biological mechanism for the regulation of cellular processes such as gene expression, cell signaling, development, and apoptosis. In transcriptional regulation, specific proteolysis regulates the localization and activity of many regulatory factors. The C1 factor (HCF), a cellular transcription factor and coactivator, undergoes site-specific proteolytic processing at a series of unusual amino acid reiterations to generate a family of amino- and carboxyl-terminal polypeptides that remain tightly associated. Expression and purification of bacterially expressed domains of the C1 factor identifies an autocatalytic activity that is responsible for the specific cleavage of the reiterations. In addition, coexpression of the autocatalytic domain with a heterologous protein containing a target cleavage site demonstrates that the C1 protease may also function in trans.
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