ArticleProceedings of the National Academy of Sciences of the United States of America2000
A sea urchin genome project: sequence scan, virtual map, and additional resources.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 136 citations in OpenAlex.
- Deep homology of aScience advances · 2025Article
- Local Genomic Instability of theGenes · 2024Article
- The complex set of internal repeats in SpTransformer protein sequences result in multiple but limited alternative alignments.Frontiers in immunology · 2022Article
- Sequence Diversity, Locus Structure, and Evolutionary History of theFrontiers in immunology · 2021Article
- Techniques for analyzing gene expression using BAC-based reporter constructs.Methods in cell biology · 2019Review
- Developmental effector gene regulation: Multiplexed strategies for functional analysis.Developmental biology · 2019Article
- Bacterial artificial chromosomes as recombinant reporter constructs to investigate gene expression and regulation in echinoderms.Briefings in functional genomics · 2018Review
- TheFrontiers in immunology · 2017Review
- Echinobase: an expanding resource for echinoderm genomic information.Database : the journal of biological databases and curation · 2017Article
- Short tandem repeats, segmental duplications, gene deletion, and genomic instability in a rapidly diversified immune gene family.BMC genomics · 2016Article
- An Elk transcription factor is required for Runx-dependent survival signaling in the sea urchin embryo.Developmental biology · 2016Article
- Eric Davidson: Steps to a gene regulatory network for development.Developmental biology · 2016Article
- Do echinoderm genomes measure up?Marine genomics · 2015Review
- Cis-regulatory logic driving glial cells missing: self-sustaining circuitry in later embryogenesis.Developmental biology · 2012Article
- Current Status of Echinoderm Genome Analysis - What do we Know?Current genomics · 2012Article
- In silico characterization of the neural alpha tubulin gene promoter of the sea urchin embryo Paracentrotus lividus by phylogenetic footprinting.Molecular biology reports · 2012Article
- An Sp185/333 gene cluster from the purple sea urchin and putative microsatellite-mediated gene diversification.BMC genomics · 2010Article
- Intragenomic evolution of a transcriptional enhancer in the genome of Strongylocentrotus purpuratus.Marine genomics · 2009Article
- The 48-kDa alternative translation isoform of PP2A:B56epsilon is required for Wnt signaling during midbrain-hindbrain boundary formation.The Journal of biological chemistry · 2009Article
- SpBase: the sea urchin genome database and web site.Nucleic acids research · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 2 countries.
Funding
Abstract
Results of a first-stage Sea Urchin Genome Project are summarized here. The species chosen was Strongylocentrotus purpuratus, a research model of major importance in developmental and molecular biology. A virtual map of the genome was constructed by sequencing the ends of 76,020 bacterial artificial chromosome (BAC) recombinants (average length, 125 kb). The BAC-end sequence tag connectors (STCs) occur an average of 10 kb apart, and, together with restriction digest patterns recorded for the same BAC clones, they provide immediate access to contigs of several hundred kilobases surrounding any gene of interest. The STCs survey >5% of the genome and provide the estimate that this genome contains approximately 27,350 protein-coding genes. The frequency distribution and canonical sequences of all middle and highly repetitive sequence families in the genome were obtained from the STCs as well. The 500-kb Hox gene complex of this species is being sequenced in its entirety. In addition, arrayed cDNA libraries of >10(5) clones each were constructed from every major stage of embryogenesis, several individual cell types, and adult tissues and are available to the community. The accumulated STC data and an expanding expressed sequence tag database (at present including >12, 000 sequences) have been reported to GenBank and are accessible on public web sites.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.