ArticleApplied and environmental microbiology2000
Purification and biochemical characterization of mutacin I from the group I strain of Streptococcus mutans, CH43, and genetic analysis of mutacin I biosynthesis genes.
Article in Applied and environmental microbiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 100 citations in OpenAlex.
- The human microbiome as a source of novel bioactive natural products: structures, bioactivities, and biosynthetic insights.Journal of natural medicines · 2026Review
- The MutRS quorum-sensing system controls lantibiotic mutacin production in the human pathogenProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Opposing genetic polymorphisms of two ABC transporters contribute to the variation of nukacin resistance inApplied and environmental microbiology · 2024Article
- [Latest Findings on Polyketides/Non-ribosomal Peptides That Are Secondary Metabolites ofSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2023Review
- Gene Rearrangement and Modification of Immunity Factors Are Correlated with the Insertion of Bacteriocin Cassettes in Streptococcus mutans.Microbiology spectrum · 2022Article
- Comprehensive analysis of bacteriocins in Streptococcus mutans.Scientific reports · 2021Article
- Complete Genome Sequences of Two Mutacin-Producing Streptococcus mutans Strains, T8 and UA140.Microbiology resource announcements · 2020Article
- Genome-Guided Mass Spectrometry Expedited the Discovery of Paraplantaricin TC318, a Lantibiotic Produced byFrontiers in microbiology · 2020Article
- Virulence ofJournal of clinical and experimental dentistry · 2020Article
- A Chemical Biology Approach to Understanding Molecular Recognition of Lipid II by Nisin(1-12): Synthesis and NMR Ensemble Analysis of Nisin(1-12) and Analogues.Chemistry (Weinheim an der Bergstrasse, Germany) · 2019Article
- Molecular Recognition of Lipid II by Lantibiotics: Synthesis and Conformational Studies of Analogues of Nisin and Mutacin Rings A and B.The Journal of organic chemistry · 2019Article
- Genome mining unveils widespread natural product biosynthetic capacity in human oral microbe Streptococcus mutans.Scientific reports · 2016Article
- Bacteriocin expression in sessile and planktonic populations of Escherichia coli.The Journal of antibiotics · 2015Article
- Preparation of Specific Polyclonal Antibody Against the Recombinant Mutacin Produced by sfGFP Fusion Protein Technology.The open microbiology journal · 2015Article
- A conserved streptococcal membrane protein, LsrS, exhibits a receptor-like function for lantibiotics.Journal of bacteriology · 2014Article
- SmbFT, a putative ABC transporter complex, confers protection against the lantibiotic Smb in Streptococci.Journal of bacteriology · 2013Article
- Involvement of the novel two-component NsrRS and LcrRS systems in distinct resistance pathways against nisin A and nukacin ISK-1 in Streptococcus mutans.Applied and environmental microbiology · 2013Article
- Genetic variability of mutans streptococci revealed by wide whole-genome sequencing.BMC genomics · 2013Article
- Article
- The mutacins of Streptococcus mutans: regulation and ecology.Molecular oral microbiology · 2012Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Previously, we reported isolation and characterization of mutacin III and genetic analysis of mutacin III biosynthesis genes from the group III strain of Streptococcus mutans, UA787 (F. Qi, P. Chen, and P. W. Caufield, Appl. Environ. Microbiol. 65:3880-3887, 1999). During the same process of isolating the mutacin III structural gene, we also cloned the structural gene for mutacin I. In this report, we present purification and biochemical characterization of mutacin I from the group I strain CH43 and compare mutacin I and mutacin III biosynthesis genes. The mutacin I biosynthesis gene locus consists of 14 genes in the order mutR, -A, -A', -B, -C, -D, -P, -T, -F, -E, -G, orfX, orfY, orfZ. mutA is the structural gene for mutacin I, while mutA' is not required for mutacin I activity. DNA and protein sequence analysis revealed that mutacins I and III are homologous to each other, possibly arising from a common ancestor. The mature mutacin I is 24 amino acids in size and has a molecular mass of 2, 364 Da. Ethanethiol modification and peptide sequencing of mutacin I revealed that it contains six dehydrated serines, four of which are probably involved with thioether bridge formation. Comparison of the primary sequence of mutacin I with that of mutacin III and epidermin suggests that mutacin I likely has the same bridging pattern as epidermin.
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