ArticleApplied and environmental microbiology2000
Requirement of autolytic activity for bacteriocin-induced lysis.
Article in Applied and environmental microbiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 59 citations in OpenAlex.
- Antimicrobial Peptides (Bacteriocins) Produced by Lactococcus lactis and Pediococcus pentosaceus Strains with Activity Against Clinical and Food-Borne Pathogens.Probiotics and antimicrobial proteins · 2025Article
- Antimicrobial Activity ofMicroorganisms · 2021Article
- Gene-Trait Matching and Prevalence of Nisin Tolerance Systems inFrontiers in bioengineering and biotechnology · 2021Article
- The pneumococcal social network.PLoS pathogens · 2020Review
- Intraguild predation provides a selection mechanism for bacterial antagonistic compounds.Proceedings. Biological sciences · 2012Review
- LytF, a novel competence-regulated murein hydrolase in the genus Streptococcus.Journal of bacteriology · 2012Article
- The autolysin LytA contributes to efficient bacteriophage progeny release in Streptococcus pneumoniae.Journal of bacteriology · 2009Article
- Reduced lysis upon growth of Lactococcus lactis on galactose is a consequence of decreased binding of the autolysin AcmA.Applied and environmental microbiology · 2008Article
- Thermophilin 110: a bacteriocin of Streptococcus thermophilus ST110.Current microbiology · 2005Article
- Competence-programmed predation of noncompetent cells in the human pathogen Streptococcus pneumoniae: genetic requirements.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Antibacterial activities of nisin Z encapsulated in liposomes or produced in situ by mixed culture during cheddar cheese ripening.Applied and environmental microbiology · 2002Article
- Inhibition of Listeria innocua in cheddar cheese by addition of nisin Z in liposomes or by in situ production in mixed culture.Applied and environmental microbiology · 2002Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bacteriocin produced by Lactococcus lactis IFPL105 is bactericidal against several Lactococcus and Lactobacillus strains. Addition of the bacteriocin to exponential-growth-phase cells resulted in all cases in bacteriolysis. The bacteriolytic response of the strains was not related to differences in sensitivity to the bacteriocin and was strongly reduced in the presence of autolysin inhibitors (Co(2+) and sodium dodecyl sulfate). When L. lactis MG1363 and its derivative deficient in the production of the major autolysin AcmA (MG1363acmADelta1) were incubated with the bacteriocin, the latter did not lyse and no intracellular proteins were released into the medium. Incubation of cell wall fragments of L. lactis MG1363, or of L. lactis MG1363acmADelta1 to which extracellular AcmA was added, in the presence or absence of the bacteriocin had no effect on the speed of cell wall degradation. This result indicates that the bacteriocin does not degrade cell walls, nor does it directly activate the autolysin AcmA. The autolysin was also responsible for the observed lysis of L. lactis MG1363 cells during incubation with nisin or the mixture of lactococcins A, B, and M. The results presented here show that lysis of L. lactis after addition of the bacteriocins is caused by the resulting cell damage, which promotes uncontrolled degradation of the cell walls by AcmA.
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