ArticleClinical & experimental metastasis1999
Functional cloning of ARM-1, an adhesion-regulating molecule upregulated in metastatic tumor cells.
Article in Clinical & experimental metastasis, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Nutrigenomic insights and cardiovascular benefits of blackberry (Rubus ulmifolius Schott.) and mugwort (Artemisia campestris L.).Experimental physiology · 2025Article
- Early and consistent overexpression of ADRM1 in ovarian high-grade serous carcinoma.Journal of ovarian research · 2017Article
- The Role of Glycosylation in Breast Cancer Metastasis and Cancer Control.Frontiers in oncology · 2015Review
- Amplification Target ADRM1: Role as an Oncogene and Therapeutic Target for Ovarian Cancer.International journal of molecular sciences · 2013Article
- Structure characterization of the 26S proteasome.Biochimica et biophysica acta · 2011Review
- Regulators of the proteasome pathway, Uch37 and Rpn13, play distinct roles in mouse development.PloS one · 2010Article
- Regulation of NF-kappaB activity and inducible nitric oxide synthase by regulatory particle non-ATPase subunit 13 (Rpn13).Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Adrm1 interacts with Atp6v0d2 and regulates osteoclast differentiation.Biochemical and biophysical research communications · 2009Article
- Reduced paxillin expression contributes to the antimetastatic effect of 4-hydroxycoumarin on B16-F10 melanoma cells.Cancer cell international · 2008Article
- hRpn13/ADRM1/GP110 is a novel proteasome subunit that binds the deubiquitinating enzyme, UCH37.The EMBO journal · 2006Article
- A Phg2-Adrm1 pathway participates in the nutrient-controlled developmental response in Dictyostelium.Molecular biology of the cell · 2006Article
- A novel proteasome interacting protein recruits the deubiquitinating enzyme UCH37 to 26S proteasomes.The EMBO journal · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Interactions of tumor cells with the endothelium and tissue stroma are considered to be critical steps in metastasis formation and progression of cancer. To identify cellular receptors that mediate the binding of tumor cells to endothelium, a murine T cell lymphoma-derived expression library was screened for adhesion-inducing cDNA clones. We identified a novel cell adhesion-promoting molecule, termed ARM-1 (adhesion regulating molecule-1), which is homologous to a human Mr 110,000 tumor-associated antigen. The ARM-1 cDNA codes for a type I transmembrane protein of 407 amino acids with potential O- and N-glycosylation sites that does not belong to any of the known families of cell adhesion molecules. Overexpression of ARM-1 in 293T human embryonic kidney cells significantly increased adhesion to different endothelial cells. ARM-1 expression in 293T cells did not alter integrin expression or beta1-integrin-mediated cell adhesion. Northern blot analysis of human breast cancer cell lines revealed 3- to 5-fold elevated ARM-1 mRNA levels in metastatic as compared to non-metastatic cells. In conclusion, we have identified ARM-1 as a novel cell adhesion-promoting receptor that is upregulated in metastatic cancer cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.