ArticleOncogene2000
Identification and characterization of genes upregulated in cells transformed by v-Jun.
Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 28 citations in OpenAlex.
- PDLIM4/RIL-mediated regulation of Src and malignant properties of breast cancer cells.Oncotarget · 2020Article
- JUN-CCAAT/enhancer-binding protein complexes inhibit surfactant-associated protein B promoter activity.American journal of respiratory cell and molecular biology · 2011Article
- Actin cytoskeleton remodeling by the alternatively spliced isoform of PDLIM4/RIL protein.The Journal of biological chemistry · 2011Article
- Localization of reversion-induced LIM protein (RIL) in the rat central nervous system.Acta histochemica et cytochemica · 2009Article
- Marek's disease virus Meq transforms chicken cells via the v-Jun transcriptional cascade: a converging transforming pathway for avian oncoviruses.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- The interaction of PTP-BL PDZ domains with RIL: an enigmatic role for the RIL LIM domain.Molecular biology reports · 2004Article
- Artificial oncoproteins: modified versions of the yeast bZip protein GCN4 induce cellular transformation.Oncogene · 2003Article
- v-Jun downregulates the SPARC target gene by binding to the proximal promoter indirectly through Sp1/3.Oncogene · 2003Article
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- v-Jun stimulates both cdk2 kinase activity and G1/S progression via transcriptional repression of p21 CIP1.Oncogene · 2003Article
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- Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity.Oncogene · 2001Review
- Jun, the oncoprotein.Oncogene · 2001Review
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- Expression of a down-regulated target, SSeCKS, reverses v-Jun-induced transformation of 10T1/2 murine fibroblasts.Oncogene · 2001Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The transcription factor Jun (c-Jun) functions as a recipient of extracellular growth signals and converts them into patterns of gene expression. An oncogenic variant of c-Jun was isolated from the acutely transforming retrovirus ASV17. Overexpression of this viral Jun (v-Jun) induces transformation of chicken embryo fibroblasts (CEF) in culture and fibrosarcomas in chickens. v-Jun is a constitutively active form of c-Jun and transforms cells presumably by deregulating the expression of specific target genes. In this report, we describe six genes whose transcripts are upregulated in v-Jun-transformed CEF. Three of these genes show homology to known mammalian genes, to MAP kinase phosphatase 2 (MKP-2), to reversion-induced LIM protein (RIL) and to cytokine-inducible SH2-containing protein (CIS). Northern blot analysis, using CEF infected with various Jun mutants or an estrogen-regulatable Jun chimera, revealed distinct induction patterns of individual targets by v-Jun. The chicken RIL homolog showed an expression pattern tightly correlated with the activity of v-Jun. Its expression is also transformation-dependent, suggesting a role for this gene in v-Jun transformation. The newly identified v-Jun targets can serve as molecular markers in the v-Jun transformation process. Oncogene (2000) 19, 3537 - 3545
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.