Evidence map›Paper›PMID 10918574›Full record

ArticleOncogene2000

Cooperative induction of mammary tumorigenesis by TGFalpha and Wnts.

J A Schroeder, K L Troyer, D C Lee

Abstract read
PubMed Publisher
In one paragraph

Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 32 citations in OpenAlex.

  1. TGF-BioMed research international · 2018
    Trial
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Intracellular MUC1 peptides inhibit cancer progression.Clinical cancer research : an official journal of the American Association for Cancer Research · 2009
    Article
  8. Article
  9. Myristoylated Naked2 escorts transforming growth factor alpha to the basolateral plasma membrane of polarized epithelial cells.Proceedings of the National Academy of Sciences of the United States of America · 2004
    Article
  10. The transforming activity of Wnt effectors correlates with their ability to induce the accumulation of mammary progenitor cells.Proceedings of the National Academy of Sciences of the United States of America · 2004
    Article
  11. Review
  12. Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

J A SchroederDepartment of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill 27599-7260, USA.
K L Troyer
D C Lee
University of North Carolina at Chapel Hill · US

Funding

CANCER CELL BIOLOGY TRAINING PROGRAMT32CA071341 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHANNING J. DER, Yuliya Pylayeva-Gupta · 1996 to 2026
$5.0M
GROWTH FACTOR INDUCED BREAST CANCERR01CA061896 · NCI · UNIVERSITY OF NORTH CAROLINA CHAPEL HILL · PI LEE, DAVID C · 1994 to 2004
$1.7M
NCI NIH HHS CA61896NCI NIH HHS CA71341
6 · The paper itself

Abstract

We previously reported that multiparous WAP-TGFalpha transgenic mice develop mammary gland carcinomas with complete incidence. TGFalpha-induced tumors appear stochastically and with relatively long latency, indicating an additional requirement for other genetic alterations. To identify genes that cooperate with TGFalpha in mammary tumorigenesis, we used a retroviral insertion approach featuring a cloned and infectious hybrid MMTV (C3H/Mtv-1; (Shackleford and Varmus, 1988)). Tumor latency was decreased approximately 30% in MMTV-infected WAP-TGFalpha transgenic animals compared to noninfected transgenic controls, and > 30% of the corresponding tumors displayed evidence of integrated C3H/Mtv-1 DNA. PCR-based analyses of DNAs from two virus-infected, transgenic tumors revealed integration of hybrid MMTV in 3' untranslated exons of the Wnt-1 or Wnt-3 oncogenes. Moreover, Northern blots confirmed dramatic induction of Wnt-1 or Wnt-3 transcripts in the respective tumors, indicating that MMTV integration resulted in activated expression of these genes. Semiquantitative RT-PCR analyses showed that overexpression of Wnt-1 or Wnt-3 was a common occurrence in MMTV-infected WAP-TGFalpha tumors, and some noninfected WAP-TGFalpha tumors also showed evidence of elevated Wnt-3 transcripts. Collectively, these results reveal cooperative induction of mammary gland tumorigenesis by simultaneous deregulation of EGF-like (TGFalpha) and Wnt growth factors.

Indexed as

Zebrafish ProteinsAnimalsBinding SitesCell Line, TransformedDNAFemaleGene ExpressionMammary Neoplasms, ExperimentalMammary Tumor Virus, MouseMiceMice, Inbred C57BLMice, TransgenicMilk ProteinsProteinsProto-Oncogene ProteinsTransforming Growth Factor alphaDNAMilk ProteinsProteinsProto-Oncogene ProteinsTransforming Growth Factor alphawhey acidic proteinsWnt1 ProteinWnt1 protein, mouseWnt3 ProteinWnt3 protein, mouseWnt ProteinsZebrafish Proteins

Identifiers

PMID10918574
OpenAlexW2322247533

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.