ArticleMolecular and cellular biology2000
A common motif within the negative regulatory regions of multiple factors inhibits their transcriptional synergy.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
68 citing papers in PubMed, 219 citations in OpenAlex.
- Central role of SUMOylation in the regulation of chromatin interactions and transcriptional outputs of the androgen receptor in prostate cancer cells.Nucleic acids research · 2024Article
- Review
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- SUMOylation regulates the protein network and chromatin accessibility at glucocorticoid receptor-binding sites.Nucleic acids research · 2021Article
- Sumoylation of transcription factor ETV1 modulates its oncogenic potential in prostate cancer.International journal of clinical and experimental pathology · 2021Article
- SUMOylation in the control of cholesterol homeostasis.Open biology · 2020Review
- SUMOylation Regulates Transcription by the Progesterone Receptor A Isoform in a Target Gene Selective Manner.Diseases (Basel, Switzerland) · 2018Article
- Regulatory and Mechanistic Actions of Glucocorticoids on T and Inflammatory Cells.Frontiers in endocrinology · 2018Review
- Modifications to glucocorticoid and progesterone receptors alter cell fate in breast cancer.Journal of molecular endocrinology · 2016Review
- Temporal variability of glucocorticoid receptor activity is functionally important for the therapeutic action of fluoxetine in the hippocampus.Molecular psychiatry · 2016Article
- Undoing SUMO aids polyQ AR.Oncotarget · 2015Article
- Disrupting SUMOylation enhances transcriptional function and ameliorates polyglutamine androgen receptor-mediated disease.The Journal of clinical investigation · 2015Article
- SUMOylation regulates the chromatin occupancy and anti-proliferative gene programs of glucocorticoid receptor.Nucleic acids research · 2014Article
- Bifunctional ligands allow deliberate extrinsic reprogramming of the glucocorticoid receptor.Molecular endocrinology (Baltimore, Md.) · 2014Article
- RSUME enhances glucocorticoid receptor SUMOylation and transcriptional activity.Molecular and cellular biology · 2013Article
- Sumoylation of Krüppel-like factor 4 inhibits pluripotency induction but promotes adipocyte differentiation.The Journal of biological chemistry · 2013Article
- The BTB-containing protein Kctd15 is SUMOylated in vivo.PloS one · 2013Article
- PIASγ enhanced SUMO-2 modification of Nurr1 activation-function-1 domain limits Nurr1 transcriptional synergy.PloS one · 2013Article
- The in vivo role of androgen receptor SUMOylation as revealed by androgen insensitivity syndrome and prostate cancer mutations targeting the proline/glycine residues of synergy control motifs.The Journal of biological chemistry · 2012Article
- Controlling a master switch of adipocyte development and insulin sensitivity: covalent modifications of PPARγ.Biochimica et biophysica acta · 2012Review
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
DNA regulatory elements frequently harbor multiple recognition sites for several transcriptional activators. The response mounted from such compound response elements is often more pronounced than the simple sum of effects observed at single binding sites. The determinants of such transcriptional synergy and its control, however, are poorly understood. Through a genetic approach, we have uncovered a novel protein motif that limits the transcriptional synergy of multiple DNA-binding regulators. Disruption of these conserved synergy control motifs (SC motifs) selectively increases activity at compound, but not single, response elements. Although isolated SC motifs do not regulate transcription when tethered to DNA, their transfer to an activator lacking them is sufficient to impose limits on synergy. Mechanistic analysis of the two SC motifs found in the glucocorticoid receptor N-terminal region reveals that they function irrespective of the arrangement of the receptor binding sites or their distance from the transcription start site. Proper function, however, requires the receptor's ligand-binding domain and an engaged dimer interface. Notably, the motifs are not functional in yeast and do not alter the effect of p160 coactivators, suggesting that they require other nonconserved components to operate. Many activators across multiple classes harbor seemingly unrelated negative regulatory regions. The presence of SC motifs within them, however, suggests a common function and identifies SC motifs as critical elements of a general mechanism to modulate higher-order interactions among transcriptional regulators.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.