ArticleMolecular and cellular biology2000
Genetic interactions between TFIIS and the Swi-Snf chromatin-remodeling complex.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 73 citations in OpenAlex.
- Swi/Snf chromatin remodeling regulates transcriptional interference and gene repression.Molecular cell · 2024Article
- Swi/Snf Chromatin Remodeling Regulates Transcriptional Interference and Gene Repression.bioRxiv : the preprint server for biology · 2023Article
- Review
- Accumulation of unacetylatable Snf2p at the INO1 promoter is detrimental to remodeler recycling supply for CUP1 induction.PloS one · 2020Article
- The chromatin remodeler ZmCHB101 impacts expression of osmotic stress-responsive genes in maize.Plant molecular biology · 2018Article
- Rad9 interacts with Aft1 to facilitate genome surveillance in fragile genomic sites under non-DNA damage-inducing conditions in S. cerevisiae.Nucleic acids research · 2014Article
- The SWI/SNF chromatin remodeling complex influences transcription by RNA polymerase I in Saccharomyces cerevisiae.PloS one · 2013Article
- Deletion of a subgroup of ribosome-related genes minimizes hypoxia-induced changes and confers hypoxia tolerance.Physiological genomics · 2011Article
- The multifunctional Ccr4-Not complex directly promotes transcription elongation.Genes & development · 2011Article
- The YEATS domain of Taf14 in Saccharomyces cerevisiae has a negative impact on cell growth.Molecular genetics and genomics : MGG · 2010Article
- The basal initiation machinery: beyond the general transcription factors.Current opinion in cell biology · 2009Review
- Spn1 regulates the recruitment of Spt6 and the Swi/Snf complex during transcriptional activation by RNA polymerase II.Molecular and cellular biology · 2008Article
- The transcription elongation factor TFIIS is a component of RNA polymerase II preinitiation complexes.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- The Swi/Snf complex is important for histone eviction during transcriptional activation and RNA polymerase II elongation in vivo.Molecular and cellular biology · 2007Article
- Transcription through chromatin by RNA polymerase II: histone displacement and exchange.Mutation research · 2007Review
- RSC exploits histone acetylation to abrogate the nucleosomal block to RNA polymerase II elongation.Molecular cell · 2006Article
- Genetic interactions between TFIIF and TFIIS.Genetics · 2006Article
- Transcription elongation factor S-II is required for definitive hematopoiesis.Molecular and cellular biology · 2006Article
- Mutations in the Saccharomyces cerevisiae RPB1 gene conferring hypersensitivity to 6-azauracil.Genetics · 2006Article
- Simultaneous recruitment of coactivators by Gcn4p stimulates multiple steps of transcription in vivo.Molecular and cellular biology · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The eukaryotic transcript elongation factor TFIIS enables RNA polymerase II to read through blocks to elongation in vitro and interacts genetically with a variety of components of the transcription machinery in vivo. In Saccharomyces cerevisiae, the gene encoding TFIIS (PPR2) is not essential, and disruption strains exhibit only mild phenotypes and an increased sensitivity to 6-azauracil. The nonessential nature of TFIIS encouraged the use of a synthetic lethal screen to elucidate the in vivo roles of TFIIS as well as provide more information on other factors involved in the regulation of transcript elongation. Several genes were identified that are necessary for either cell survival or robust growth when the gene encoding TFIIS has been disrupted. These include UBP3, KEX2, STT4, and SWI2/SNF2. SWI1 and SNF5 disruptions were also synthetically lethal with ppr2Delta, suggesting that the reduced ability to remodel chromatin confers the synthetic phenotype. The synthetic phenotypes show marked osmosensitivity and cytoskeletal defects, including a terminal hyperelongated bud phenotype with the Swi-Snf complex. These results suggest that genes important in osmoregulation, cell membrane synthesis and integrity, and cell division may require the Swi-Snf complex and TFIIS for efficient transcription. The detection of these genetic interactions provides another functional link between the Swi-Snf complex and the elongation machinery.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.