ArticleMolecular and cellular biology2000
A U-rich element in the 5' untranslated region is necessary for the translation of p27 mRNA.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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Who cites it
64 citing papers in PubMed, 134 citations in OpenAlex.
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- An Unanticipated Modulation of Cyclin-Dependent Kinase Inhibitors: The Role of Long Non-Coding RNAs.Cells · 2022Review
- Review
- Reduced expression of the RNA-binding protein HuD in pancreatic neuroendocrine tumors correlates with low p27The Journal of pathology · 2018Article
- Development of bicistronic expression system for the enhanced and reliable production of recombinant proteins in Leuconostoc citreum.Scientific reports · 2018Article
- Cold-inducible RNA-binding protein (CIRP) induces translation of the cell-cycle inhibitor p27Kip1.Nucleic acids research · 2018Article
- The RNA-binding protein Celf1 post-transcriptionally regulates p27Kip1 and Dnase2b to control fiber cell nuclear degradation in lens development.PLoS genetics · 2018Article
- MEN4 andEndocrine-related cancer · 2017Review
- Target-dependent biogenesis of cognate microRNAs in human cells.Nature communications · 2016Article
- PKM2 uses control of HuR localization to regulate p27 and cell cycle progression in human glioblastoma cells.International journal of cancer · 2016Article
- Translate to divide: сontrol of the cell cycle by protein synthesis.Microbial cell (Graz, Austria) · 2015Review
- p27Kip1 inhibits the cell cycle through non-canonical G1/S phase-specific gatekeeper mechanism.Cell cycle (Georgetown, Tex.) · 2015Article
- Role of RNA structure motifs in IRES-dependent translation initiation of the coxsackievirus B3: new insights for developing live-attenuated strains for vaccines and gene therapy.Molecular biotechnology · 2013Review
- Deficiency of the cyclin-dependent kinase inhibitor, CDKN1B, results in overgrowth and neurodevelopmental delay.Human mutation · 2013Article
- Insights from the HuR-interacting transcriptome: ncRNAs, ubiquitin pathways, and patterns of secondary structure dependent RNA interactions.Molecular genetics and genomics : MGG · 2012Article
- The regulation of AβPP expression by RNA-binding proteins.Ageing research reviews · 2012Review
- Including the p53 ELAV-like protein-binding site in vector cassettes enhances transgene expression in rat submandibular gland.Oral diseases · 2012Article
- Far upstream element binding protein 1 activates translation of p27Kip1 mRNA through its internal ribosomal entry site.The international journal of biochemistry & cell biology · 2011Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Increased translation of p27 mRNA correlates with withdrawal of cells from the cell cycle. This raised the possibility that antimitogenic signals might mediate their effects on p27 expression by altering complexes that formed on p27 mRNA, regulating its translation. In this report, we identify a U-rich sequence in the 5' untranslated region (5'UTR) of p27 mRNA that is necessary for efficient translation in proliferating and nonproliferating cells. We show that a number of factors bind to the 5'UTR in vitro in a manner dependent on the U-rich element, and their availability in the cytosol is controlled in a growth- and cell cycle-dependent fashion. One of these factors is HuR, a protein previously implicated in mRNA stability, transport, and translation. Another is hnRNP C1 and C2, proteins implicated in mRNA processing and the translation of a specific subset of mRNAs expressed in differentiated cells. In lovastatin-treated MDA468 cells, the mobility of the associated hnRNP C1 and C2 proteins changed, and this correlated with increased p27 expression. Together, these data suggest that the U-rich dependent RNP complex on the 5'UTR may regulate the translation of p27 mRNA and may be a target of antimitogenic signals.
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Registered trials
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