ArticleJournal of clinical pathology2000
ALK expression in extranodal anaplastic large cell lymphoma favours systemic disease with (primary) nodal involvement and a good prognosis and occurs before dissemination.
Article in Journal of clinical pathology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 106 citations in OpenAlex.
- Article
- Review
- ALK-negative primary cutaneous T-cell anaplastic large cell lymphoma, myxoid variant; masquerading as sarcoma: unveiling the diagnostic dilemma.BMJ case reports · 2021Article
- ALK+ Anaplastic large cell lymphoma with extensive cardiac involvement: A rare case report and review of the literature.Autopsy & case reports · 2021Article
- Anaplastic Large T-Cell Lymphoma in the Intestine of Dogs.Veterinary pathology · 2019Article
- Article
- Small cell variant of ALK-positive anaplastic large cell lymphoma with primary subcutaneous presentation: A case report.Medicine · 2018Article
- Anaplastic Lymphoma Kinase in Cutaneous Malignancies.Cancers · 2017Review
- The long non-coding RNA LINC01013 enhances invasion of human anaplastic large-cell lymphoma.Scientific reports · 2017Article
- Cytotoxic T-cell and NK-cell lymphomas: current questions and controversies.The American journal of surgical pathology · 2014Review
- Development of a plaque infiltrated with large CD30+ T cells over a silicone-containing device in a patient with history of Sézary syndrome.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2013Article
- ALK-positive anaplastic large cell lymphoma limited to the skin: clinical, histopathological and molecular analysis of 6 pediatric cases. A report from the ALCL99 study.Haematologica · 2013Review
- Implant-associated anaplastic large cell lymphoma of the breast: Insight into a poorly understood disease.The Canadian journal of plastic surgery = Journal canadien de chirurgie plastique · 2013Article
- Primary anaplastic lymphoma kinase-negative anaplastic large-cell lymphoma of the breast in a male patient.The British journal of radiology · 2012Article
- Worse disease-free survival in never-smokers with ALK+ lung adenocarcinoma.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2012Article
- Clonal T-cell receptor β-chain gene rearrangements in differential diagnosis of lymphomatoid papulosis from skin metastasis of nodal anaplastic large-cell lymphoma.Archives of dermatology · 2011Article
- An update in management of noncutaneous T-cell lymphomas.Advances in hematology · 2010Article
- Peripheral T-cell lymphoma: review and updates of current management strategies.Advances in hematology · 2010Article
- Rare lymphoid malignancies of the breast: a report of two cases illustrating potential diagnostic pitfalls.Journal of hematopathology · 2009Article
- Primary systemic anaplastic large cell lymphoma in Korean adults: 11 years' experience at Asan Medical Center.Yonsei medical journal · 2008Article
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8 authors at 4 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsIn anaplastic large cell lymphoma (ALCL), the site of origin has been described as an important prognostic factor. Recently, a fusion protein containing anaplastic lymphoma kinase (ALK) was described in systemic nodal ALCL, and shown to be associated with a good prognosis. The aims of this study were to investigate whether the presence of ALK protein differs between ALCL of different sites of origin; to determine whether ALK expression occurs before dissemination to other sites; and, finally, to investigate whether the site of origin remains a prognostic parameter in ALK negative ALCL.
methodsALK expression, as detected by immunohistochemistry using the monoclonal antibodies ALK1 and ALKc, was studied in 85 ALCLs from different sites of origin. In 22 patients, ALK expression was studied in multiple biopsies from different sites (including 13 skin, 16 lymph node, and nine other). Overall survival time was analysed using the Kaplan Meier method.
resultsALK expression was found in 20 of 51 systemic ALCLs with (primary) nodal involvement. No ALK expression was found in 15 primary cutaneous, 14 gastrointestinal, and five nasal ALCLs. Multiple and subsequent biopsies of patients showed ALK expression to be identical to that seen in the primary diagnostic biopsy. Kaplan Meier survival curves showed that in ALK negative ALCLs originating from different sites, primary cutaneous cases are associated with an excellent overall survival, whereas the other cases show a comparable five years survival of less than 40%.
conclusionsIf present, ALK expression favours systemic ALCL with (primary) nodal involvement, and can be used in differentiating between extranodal involvement of systemic (nodal) ALCL and primary extranodal ALCL. ALK is expressed consistently in multiple biopsies of a given patient, indicating that the chromosomal abnormality leading to aberrant ALK expression occurs before dissemination to other sites. Finally, in ALK negative non-cutaneous ALCLs, different sites of origin show comparable poor survival.
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