ArticleTransplantation2000
Durable donor-specific T and B cell tolerance in rhesus macaques induced with peritransplantation anti-CD3 immunotoxin and deoxyspergualin: absence of chronic allograft nephropathy.
Article in Transplantation, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Update on Dendritic Cell-Induced Immunological and Clinical Tolerance.Frontiers in immunology · 2017Review
- Lymphocyte Activation Markers in Pediatric Kidney Transplant Recipients.International journal of biomedical science : IJBS · 2015Article
- Immunogenetic Management Software: a new tool for visualization and analysis of complex immunogenetic datasets.Immunogenetics · 2012Article
- Improving the safety of tolerance induction: chimerism and cellular co-treatment strategies applied to vascularized composite allografts.Clinical & developmental immunology · 2012Review
- Tolerance-inducing immunosuppressive strategies in clinical transplantation: an overview.Drugs · 2008Review
- The unfinished legacy of liver transplantation: emphasis on immunology.Hepatology (Baltimore, Md.) · 2006Review
- Induction of transplantation tolerance in non-human primate preclinical models.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2005Review
- The complementary roles of deletion and regulation in transplantation tolerance.Nature reviews. Immunology · 2003Review
- Islet transplantation in the twenty-first century.Immunologic research · 2002Review
- STEALTH in transplantation tolerance.Immunologic research · 2002Review
- Transplantation tolerance from a historical perspective.Nature reviews. Immunology · 2001Review
- Molecular determinants of peptide binding to two common rhesus macaque major histocompatibility complex class II molecules.Journal of virology · 2001Article
- CD40-ligand in primate cardiac allograft and viral immunity.Immunologic research · 2001Article
Corrections and comments
- Retraction · 2006-06-27Falsification/Fabrication of Data · Investigation by Company/Institution · Investigation by ORI · Misconduct - Official Investigation(s) and/or Finding(s) · Misconduct by Author · · Juan L Contreras has NIH finding of misconduct: https://grants.nih.gov/grants/guide/notice-files/NOT-OD-09-119.html; Judith M Thomas has NIH finding of misconduct https://ori.hhs.gov/content/case-summary-thomas-judith-m
- Commented on by
- Commented on by
- Retracted
Authors and funding
9 authors.
Funding
Abstract
Tolerance induction can prevent acute kidney allograft rejection without chronic immunosuppression. It is uncertain whether specific tolerance can prevent chronic allograft nephropathy (CAN), which involves both nonimmune and immune injury. This report provides evidence that immunologically tolerant macaques, induced with immunotoxin and deoxyspergualin, developed neither acute rejection nor CAN. Long survivors, bearing MHC-mismatched grafts without chronic immunosuppression for 0.8 to 3.4 years, exhibited general immune competence with donor-specific T and B cell tolerance and no functional or histological evidence of CAN. Stringent criteria for tolerance were satisfied by specific prolongation of donor skin grafts with rapid rejection of third-party skin, followed by indefinite acceptance of a second donor kidney graft and establishment of microchimerism. Primate tolerance with documented absence of CAN may give impetus to the clinical application of tolerance.
Indexed as
Identifiers
10910269What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.