ArticleProceedings of the National Academy of Sciences of the United States of America2000
In vivo immunological function of mast cells derived from embryonic stem cells: an approach for the rapid analysis of even embryonic lethal mutations in adult mice in vivo.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 90 citations in OpenAlex.
- Mast cells and IgE in defense against lethality of venoms: Possible "benefit" of allergy[].Allergo journal international · 2020Article
- Visualizing structure and transitions in high-dimensional biological data.Nature biotechnology · 2019Article
- Mast Cells and IgE can Enhance Survival During Innate and Acquired Host Responses to Venoms.Transactions of the American Clinical and Climatological Association · 2017Review
- The Mast Cell-IgE Paradox: From Homeostasis to Anaphylaxis.The American journal of pathology · 2016Review
- De novo formed satellite DNA-based mammalian artificial chromosomes and their possible applications.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Review
- The tetraspanin CD63 is required for efficient IgE-mediated mast cell degranulation and anaphylaxis.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Lowered expression of heparan sulfate/heparin biosynthesis enzyme N-deacetylase/n-sulfotransferase 1 results in increased sulfation of mast cell heparin.The Journal of biological chemistry · 2011Article
- Human embryonic stem cells: a source of mast cells for the study of allergic and inflammatory diseases.Blood · 2010Article
- New developments in mast cell biology.Nature immunology · 2008Review
- Mast cell-specific Cre/loxP-mediated recombination in vivo.Transgenic research · 2008Article
- Distinct and shared transcriptomes are regulated by microphthalmia-associated transcription factor isoforms in mast cells.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
- Review
- Loss of histochemical identity in mast cells lacking carboxypeptidase A.Molecular and cellular biology · 2005Article
- Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo.The Journal of experimental medicine · 2002Article
- Differential responses of mast cell Toll-like receptors 2 and 4 in allergy and innate immunity.The Journal of clinical investigation · 2002Article
- Analyzing the roles of mast cells and basophils in host defense and other biological responses.International journal of hematology · 2002Review
- Mast cells derived from embryonic stem cells: a model system for studying the effects of genetic manipulations on mast cell development, phenotype, and function in vitro and in vivo.International journal of hematology · 2002Review
- Regulation of mast cell-mediated innate immunity during early response to bacterial infection.Clinical reviews in allergy & immunology · 2002Review
- Role of MEKK2-MEK5 in the regulation of TNF-alpha gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
An important goal of tissue engineering is to achieve reconstitution of specific functionally active cell types by transplantation of differentiated cell populations derived from normal or genetically altered embryonic stem cells in vitro. We find that mast cells derived in vitro from wild-type or genetically manipulated embryonic stem cells can survive and orchestrate immunologically specific IgE-dependent reactions after transplantation into mast cell-deficient Kit(W)/Kit(W-v) mice. These findings define a unique approach for analyzing the effects of mutations of any genes that are expressed in mast cells, including embryonic lethal mutations, in vitro or in vivo.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.