ArticleProceedings of the National Academy of Sciences of the United States of America2000
Recognition of the 300-kDa mannose 6-phosphate receptor cytoplasmic domain by 47-kDa tail-interacting protein.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 67 citations in OpenAlex.
- PLIN3: a multifaceted regulator of lipid droplet dynamics and disease pathogenesis.Medical oncology (Northwood, London, England) · 2025Review
- Protein sorting from endosomes to the TGN.Frontiers in cell and developmental biology · 2023Review
- Toward Understanding the Molecular Role of SNX27/Retromer in Human Health and Disease.Frontiers in cell and developmental biology · 2021Review
- Emerging Role of Retromer in Modulating Pathogen Growth.Trends in microbiology · 2018Review
- Luminal/extracellular domains of chimeric CI-M6PR-C proteins interfere with their retrograde endosome-to-TGN trafficking in the transient expression system.Journal of biomedical research · 2018Article
- Insulin-Like Growth Factor-II/Cation-Independent Mannose 6-Phosphate Receptor in Neurodegenerative Diseases.Molecular neurobiology · 2017Review
- A role for retromer in hepatitis C virus replication.Cellular and molecular life sciences : CMLS · 2016Article
- Expression of insulin-like growth factor family genes in clear cell renal cell carcinoma.Contemporary oncology (Poznan, Poland) · 2016Article
- Reevaluation of the requirement for TIP47 in human immunodeficiency virus type 1 envelope glycoprotein incorporation.Journal of virology · 2013Article
- Distinct cellular pools of perilipin 5 point to roles in lipid trafficking.Biochimica et biophysica acta · 2012Article
- Entry at the trans-face of the Golgi.Cold Spring Harbor perspectives in biology · 2011Review
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- Review
- Vaccinia virus p37 interacts with host proteins associated with LE-derived transport vesicle biogenesis.Virology journal · 2009Article
- Slow endocytosis of the LDL receptor-related protein 1B: implications for a novel cytoplasmic tail conformation.Experimental cell research · 2007Article
- Tail-interacting protein TIP47 is a connector between Gag and Env and is required for Env incorporation into HIV-1 virions.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Targeting of transmembrane protein shrew-1 to adherens junctions is controlled by cytoplasmic sorting motifs.Molecular biology of the cell · 2006Article
- TIP47 is a key effector for Rab9 localization.The Journal of cell biology · 2006Article
- The adaptor protein AP-4 as a component of the clathrin coat machinery: a morphological study.The Biochemical journal · 2005Article
- Rab9 GTPase regulates late endosome size and requires effector interaction for its stability.Molecular biology of the cell · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Tail-interacting 47-kDa protein (TIP47) binds the cytoplasmic domains of the cation-dependent (CD) and cation-independent (CI) mannose 6-phosphate receptors (MPRs) and is required for their transport from endosomes to the Golgi complex. TIP47 recognizes a phenylalanine-tryptophan signal in the CD-MPR. We show here that TIP47 interaction with the 163-residue CI-MPR cytoplasmic domain is highly conformation dependent and requires CI-MPR residues that are proximal to the membrane. CI-MPR cytoplasmic domain residues 1-47 are dispensable, whereas residues 48-74 are essential for high-affinity binding. However, residues 48-74 are not sufficient for high-affinity binding; residues 75-163 alone display weak affinity for TIP47, yet they contribute to the presentation of residues 48-74 in the intact protein. Independent competition binding experiments confirm that TIP47 interacts with the membrane-proximal portion of the CI-MPR cytoplasmic domain. TIP47 binding is competed by the binding of the AP-2 clathrin adaptor at (and near) residues 24-29 but not by AP-1 binding at (and near) residues 160-161. Finally, TIP47 appears to recognize a putative loop generated by the sequence PPAPRPG and other hydrophobic residues in the membrane-proximal domain. Although crystallography will be needed to define the precise interaction interface, these data provide an initial structural basis for TIP47-CI-MPR association.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.