ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Developmental regulation of a local positive autocontrol of supraoptic neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 57 citations in OpenAlex.
- Multidimensional maturation of oxytocin neurons: A principal component analysis of postnatal development.Journal of neuroendocrinology · 2026Article
- Development of the neurohypophysis: A major neuroendocrine interface.Journal of neuroendocrinology · 2026Review
- Specification of oxytocinergic and vasopressinergic circuits in the developing mouse brain.Communications biology · 2021Article
- Neonatal Oxytocin Treatment Ameliorates Autistic-Like Behaviors and Oxytocin Deficiency in Valproic Acid-Induced Rat Model of Autism.Frontiers in cellular neuroscience · 2018Article
- Dendritic Release of Neurotransmitters.Comprehensive Physiology · 2016Review
- Physiology of spontaneous [Ca(2+)]i oscillations in the isolated vasopressin and oxytocin neurones of the rat supraoptic nucleus.Cell calcium · 2016Article
- Oxytocin mediates early experience-dependent cross-modal plasticity in the sensory cortices.Nature neuroscience · 2014Article
- Ontogenesis of oxytocin pathways in the mammalian brain: late maturation and psychosocial disorders.Frontiers in neuroanatomy · 2014Review
- PVN pathways controlling energy homeostasis.Indian journal of endocrinology and metabolism · 2012Article
- Expression of exocytosis proteins in rat supraoptic nucleus neurones.Journal of neuroendocrinology · 2012Article
- Vasopressin inhibits LTP in the CA2 mouse hippocampal area.PloS one · 2012Article
- The involvement of voltage-operated calcium channels in somato-dendritic oxytocin release.PloS one · 2011Article
- The effects of apelin on the electrical activity of hypothalamic magnocellular vasopressin and oxytocin neurons and somatodendritic Peptide release.Endocrinology · 2008Article
- Central blockade of oxytocin receptors during mid-late gestation reduces amplitude of slow afterhyperpolarization in supraoptic oxytocin neurons.American journal of physiology. Endocrinology and metabolism · 2008Article
- The chemokine SDF-1/CXCL12 modulates the firing pattern of vasopressin neurons and counteracts induced vasopressin release through CXCR4.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Alcohol tolerance in large-conductance, calcium-activated potassium channels of CNS terminals is intrinsic and includes two components: decreased ethanol potentiation and decreased channel density.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Ca(2+) and frequency dependence of exocytosis in isolated somata of magnocellular supraoptic neurones of the rat hypothalamus.The Journal of physiology · 2004Article
- Interplay between presynaptic and postsynaptic activities is required for dendritic plasticity and synaptogenesis in the supraoptic nucleus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mature oxytocin (OT) and vasopressin (AVP) magnocellular neurons of the hypothalamic supraoptic nuclei (SON) autocontrol their electrical activity via somatodendritic release of their respective peptides. Because OT and AVP are synthesized early in development and could play an important role in the maturation of these neurons, we checked whether the peptides are released within the SON and act on their secreting neurons during 3 weeks of postnatal development. We used patch-clamp recordings from SON neurons in rat hypothalamic horizontal slices to show that the spontaneous electrical activity of immature SON neurons is blocked by OT or AVP receptor antagonists, demonstrating a basal somatodendritic release of the peptides. Application of OT or AVP depolarizes SON neurons and stimulates activity typical of the corresponding mature neurons. This effect is directly on SON neurons because it is recorded in dissociated neurons. Radioimmunoassays from isolated SON were used to show that each peptide facilitates its own release at a somatodendritic level, exhibiting a self-sustaining positive feedback loop. This autocontrol is not uniform during development because the proportion of neurons depolarized by the peptides, the amplitude of the depolarization, and the propensity of the peptides to facilitate their own release are maximal during the second postnatal week and decrease thereafter. These data are consistent with a role of autocontrol in the maturation of SON neurons because it is maximal during the delimited period of postnatal development that corresponds to the period of major synapse formation.
Indexed as
Identifiers
10908622PMC6772532W2108449771What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.