ArticleNucleic acids research2000
Universal bases for hybridization, replication and chain termination.
Article in Nucleic acids research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Halogenated Hypoxanthine 2'-Deoxyribonucleosides With Pyrazolo[3,4-d]Pyrimidine Skeleton: Synthesis, Crystal Structures, Physical Properties, and Impact on Watson-Crick and Purine-Purine Base Pairs.Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Article
- The Development of Non-natural Type Nucleoside to Stabilize Triplex DNA Formation against CG and TA Inversion Site.Current medicinal chemistry · 2024Review
- Expansion of the Genetic Alphabet: A Chemist's Approach to Synthetic Biology.Accounts of chemical research · 2018Article
- C2'-pyrene-functionalized triazole-linked DNA: universal DNA/RNA hybridization probes.The Journal of organic chemistry · 2012Article
- Non-natural nucleotides as probes for the mechanism and fidelity of DNA polymerases.Biochimica et biophysica acta · 2010Review
- Evolving a polymerase for hydrophobic base analogues.Journal of the American Chemical Society · 2009Article
- Ambivalent incorporation of the fluorescent cytosine analogues tC and tCo by human DNA polymerase alpha and Klenow fragment.Biochemistry · 2009Article
- Discovery, characterization, and optimization of an unnatural base pair for expansion of the genetic alphabet.Journal of the American Chemical Society · 2008Article
- Human DNA polymerase alpha uses a combination of positive and negative selectivity to polymerize purine dNTPs with high fidelity.Biochemistry · 2007Article
- Exploration of factors driving incorporation of unnatural dNTPS into DNA by Klenow fragment (DNA polymerase I) and DNA polymerase alpha.Nucleic acids research · 2005Article
- Hybridization properties and enzymatic replication of oligonucleotides containing the photocleavable 7-nitroindole base analog.Nucleic acids research · 2005Article
- The fidelity of replication of the three-base-pair set adenine/thymine, hypoxanthine/cytosine and 6-thiopurine/5-methyl-2-pyrimidinone with T7 DNA polymerase.The Biochemical journal · 2004Article
- Survey and summary: The applications of universal DNA base analogues.Nucleic acids research · 2001Review
- Parallel multiplex thermodynamic analysis of coaxial base stacking in DNA duplexes by oligodeoxyribonucleotide microchips.Nucleic acids research · 2001Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Several unnatural, predominantly hydrophobic nucleobases that pack efficiently in duplex DNA without hydrogen bonding functionalities are reported to circumvent the hydrogen bonding-based specificity, both during oligonucleotide hybridization and enzymatic DNA synthesis. The reported nucleoside analogs are efficient 'universal bases' for hybridization, template directed DNA synthesis and chain termination. Moreover, several of the universal bases function in their biological role, hybridization or replication, with an efficiency not significantly reduced relative to their natural counterparts.
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Registered trials
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