ArticleNucleic acids research2000
The identification of an endonuclease that cleaves within an HuR binding site in mRNA.
Article in Nucleic acids research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 47 citations in OpenAlex.
- The H19 lincRNA is a developmental reservoir of miR-675 that suppresses growth and Igf1r.Nature cell biology · 2012Article
- Post-Transcriptional Control of the Hypoxic Response by RNA-Binding Proteins and MicroRNAs.Frontiers in molecular neuroscience · 2011Article
- Embryonic lethal abnormal vision-like HuR-dependent mRNA stability regulates post-transcriptional expression of cyclin-dependent kinase inhibitor p27Kip1.The Journal of biological chemistry · 2010Article
- RNA-binding proteins implicated in the hypoxic response.Journal of cellular and molecular medicine · 2009Review
- The 5' terminal uracil of let-7a is critical for the recruitment of mRNA to Argonaute2.The Biochemical journal · 2009Article
- Chapter 3. Assays of adenylate uridylate-rich element-mediated mRNA decay in cells.Methods in enzymology · 2008Article
- Review
- Expression of the human RNA-binding protein HuR in Trypanosoma brucei increases the abundance of mRNAs containing AU-rich regulatory elements.Nucleic acids research · 2002Article
- Regulation of chemokine expression by antiinflammatory cytokines.Immunologic research · 2002Review
- Degradation of the unstable EP1 mRNA in Trypanosoma brucei involves initial destruction of the 3'-untranslated region.Nucleic acids research · 2001Article
- Control of cyclin-dependent kinase inhibitor p27 expression by cap-independent translation.Molecular and cellular biology · 2001Article
- The major transcription initiation site of the p27Kip1 gene is conserved in human and mouse and produces a long 5'-UTR.BMC molecular biology · 2001Article
- Mechanisms of endonuclease-mediated mRNA decay.Wiley interdisciplinary reviews. RNAReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Messenger RNAs (mRNAs) that contain U-rich elements are targeted for rapid decay. Selective inhibition of this decay results in a rapid increase in steady state level. Thus, this is an important regulatory step in gene expression. Previously, we have found that these mRNAs are selectively stabilized by a specific mRNA binding protein called HuR. The mechanism of action of HuR is not well understood. It has been postulated that HuR stabilizes mRNA by the displacement or inhibition of factors that specifically cleave or deadenyl-ate these mRNAs. In this paper, we report the identification and characterization of a novel endo-nuclease that cleaves within an HuR binding site in p27kip1 mRNA. The specificity of this endonuclease and its inhibition by HuR argue for it playing a role in the postranscriptional regulation of gene expression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.