ArticleNucleic acids research2000
The mouse L-histidine decarboxylase gene: structure and transcriptional regulation by CpG methylation in the promoter region.
Article in Nucleic acids research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 41 citations in OpenAlex.
- The Hdc GC box is critical for Hdc gene transcription and histamine-mediated anaphylaxis.The Journal of allergy and clinical immunology · 2023Article
- Histamine acts via H4-receptor stimulation to cause augmented inflammation when lipopolysaccharide is co-administered with a nitrogen-containing bisphosphonate.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022Article
- Histamine and histidine decarboxylase: Immunomodulatory functions and regulatory mechanisms.Genes to cells : devoted to molecular & cellular mechanisms · 2020Review
- Lipopolysaccharide-induced expansion of histidine decarboxylase-expressing Ly6GScientific reports · 2019Article
- Expression of Histidine Decarboxylase and Its Roles in Inflammation.International journal of molecular sciences · 2019Review
- The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis.The Journal of allergy and clinical immunology · 2018Article
- Molecular Regulation of Histamine Synthesis.Frontiers in immunology · 2018Review
- Article
- The CpG island in the murine foxl2 proximal promoter is differentially methylated in primary and immortalized cells.PloS one · 2013Article
- GABAergic inhibition of histaminergic neurons regulates active waking but not the sleep-wake switch or propofol-induced loss of consciousness.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression.Genome research · 2012Article
- Histamine deficiency promotes inflammation-associated carcinogenesis through reduced myeloid maturation and accumulation of CD11b+Ly6G+ immature myeloid cells.Nature medicine · 2011Article
- Molecular biology of histidine decarboxylase and prostaglandin receptors.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2010Review
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To investigate the regulation of mouse L-histidine decarboxylase (HDC) gene expression, we isolated genomic DNA clones encoding HDC. Structural analysis revealed that the mouse HDC gene was composed of 12 exons, spanning approximately 24 kb. Northern blotting analysis indicated that, among the cell lines examined, a high level of HDC gene expression was restricted to mature mast cell lines and an erythroblastic cell line. The gene was induced strongly in the mouse immature mast cell line P815 after incubation in the peritoneal cavity of BDF1 mice. We observed that the promoter region was demethylated in the HDC-expressing cell lines and in induced P815 cells. Interestingly, forced demethylation by 5-azacytidine (5-azaC) treatment induced high expression of HDC mRNA in P815 cells. The activity of a mouse HDC promoter-reporter construct stably transfected in P815 cells was repressed by in vitro patch-methylation. This low promoter activity of the patch-methylated reporter construct was restored after 5-azaC treatment, which demethylated the patch-methylated promoter. These results indicate that DNA methylation state of the promoter region controls HDC gene expression.
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