ArticleJournal of virology2000
Antibodies to CD9, a tetraspan transmembrane protein, inhibit canine distemper virus-induced cell-cell fusion but not virus-cell fusion.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 58 citations in OpenAlex.
- Article
- Safety and Immunogenicity ofViruses · 2024Article
- Multiple Receptors Involved in Invasion and Neuropathogenicity of Canine Distemper Virus: A Review.Viruses · 2022Review
- Tetraspanins are involved in Burkholderia pseudomallei-induced cell-to-cell fusion of phagocytic and non-phagocytic cells.Scientific reports · 2020Article
- Anti-human CD9 antibody Fab fragment impairs the internalization of extracellular vesicles and the nuclear transfer of their cargo proteins.Journal of cellular and molecular medicine · 2019Article
- Tetraspanin Assemblies in Virus Infection.Frontiers in immunology · 2018Review
- Expression of canine distemper virus receptor nectin-4 in the central nervous system of dogs.Scientific reports · 2017Article
- Tetraspanin CD9 determines invasiveness and tumorigenicity of human breast cancer cells.Oncotarget · 2015Article
- Nectin4 is an epithelial cell receptor for canine distemper virus and involved in neurovirulence.Journal of virology · 2012Article
- Canine distemper virus utilizes different receptors to infect chicken embryo fibroblasts and vero cells.Virologica Sinica · 2011Article
- Formation of syncytia is repressed by tetraspanins in human immunodeficiency virus type 1-producing cells.Journal of virology · 2009Article
- Strategies for targeting tetraspanin proteins: potential therapeutic applications in microbial infections.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2009Review
- Targeting of tetraspanin proteins--potential benefits and strategies.Nature reviews. Drug discovery · 2008Review
- Cellular proteins in influenza virus particles.PLoS pathogens · 2008Article
- CD9 clustering and formation of microvilli zippers between contacting cells regulates virus-induced cell fusion.Traffic (Copenhagen, Denmark) · 2008Article
- Tetraspanins: Small transmembrane proteins with big impact on membrane microdomain structures.Communicative & integrative biology · 2008Article
- Effect of epitope position on neutralization by anti-human immunodeficiency virus monoclonal antibody 2F5.Journal of virology · 2006Article
- A primate virus generates transformed human cells by fusion.The Journal of cell biology · 2005Article
- Tetraspanins in viral infections: a fundamental role in viral biology?Journal of virology · 2005Review
- Nearby clusters of hemagglutinin residues sustain SLAM-dependent canine distemper virus entry in peripheral blood mononuclear cells.Journal of virology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Canine distemper virus (CDV) causes a life-threatening disease in several carnivores including domestic dogs. Recently, we identified a molecule, CD9, a member of the tetraspan transmembrane protein family, which facilitates, and antibodies to which inhibit, the infection of tissue culture cells with CDV (strain Onderstepoort). Here we describe that an anti-CD9 monoclonal antibody (MAb K41) did not interfere with binding of CDV to cells and uptake of virus. In addition, in single-step growth experiments, MAb K41 did not induce differences in the levels of viral mRNA and proteins. However, the virus release of syncytium-forming strains of CDV, the virus-induced cell-cell fusion in lytically infected cultures, and the cell-cell fusion of uninfected with persistently CDV-infected HeLa cells were strongly inhibited by MAb K41. These data indicate that anti-CD9 antibodies selectively block virus-induced cell-cell fusion, whereas virus-cell fusion is not affected.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.