ArticleJournal of virology2000
Novel mouse type D endogenous proviruses and ETn elements share long terminal repeat and internal sequences.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes.Nature genetics · 2025Article
- A retrotransposon caught red-handed in a curious case of missing digits.Nature genetics · 2025Article
- Activation of endogenous retroviruses characterizes the maternal-fetal interface in the BTBR mouse model of autism spectrum disorder.Scientific reports · 2025Article
- GWAS reveals determinants of mobilization rate and dynamics of an active endogenous retrovirus of cattle.Nature communications · 2024Article
- Species-Specific Transcription Factors Associated with Long Terminal Repeat Promoters of Endogenous Retroviruses: A Comprehensive Review.Biomolecules · 2024Review
- Nested retrotransposition in the East Asian mouse genome causes the classicalCommunications biology · 2019Article
- Mouse germ line mutations due to retrotransposon insertions.Mobile DNA · 2019Review
- RNase H2, mutated in Aicardi-Goutières syndrome, promotes LINE-1 retrotransposition.The EMBO journal · 2018Article
- Article
- Friend or Foe: Epigenetic Regulation of Retrotransposons in Mammalian Oogenesis and Early Development.The Yale journal of biology and medicine · 2016Review
- Suppression subtractive hybridization method for the identification of a new strain of murine hepatitis virus from xenografted SCID mice.Archives of virology · 2015Article
- A novel intergenic ETnII-β insertion mutation causes multiple malformations in polypodia mice.PLoS genetics · 2013Article
- Next-generation sequencing identifies the Danforth's short tail mouse mutation as a retrotransposon insertion affecting Ptf1a expression.PLoS genetics · 2013Article
- Strain-specific modifier genes governing craniofacial phenotypes.Birth defects research. Part A, Clinical and molecular teratology · 2012Article
- Article
- Retrotransposon-induced heterochromatin spreading in the mouse revealed by insertional polymorphisms.PLoS genetics · 2011Article
- Protein targeting to exosomes/microvesicles by plasma membrane anchors.The Journal of biological chemistry · 2011Article
- A novel active endogenous retrovirus family contributes to genome variability in rat inbred strains.Genome research · 2010Article
- Preferential epigenetic suppression of the autonomous MusD over the nonautonomous ETn mouse retrotransposons.Molecular and cellular biology · 2009Article
- DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity.The EMBO journal · 2008Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The repetitive ETn (early transposon) family of sequences represents an active "mobile mutagen" in the mouse genome. The presence of long terminal repeats (LTRs) and other diagnostic features indicate that ETns are retrotransposons but they contain no long open reading frames or documented similarity to the genes of known retroviruses or other retroelements. Thus, the mechanisms responsible for the mobility of this family have been unknown. In this study, we used computer searches to detect a small region of previously unrecognized type D retroviral pol homology within ETn elements. This small region was used to isolate two mouse endogenous proviral elements with gag, pro, and pol genes similar to simian type D viruses. This new family of mouse endogenous proviruses, termed MusD, is present in several hundred copies in the genome. Interestingly, the MusD LTRs, 3' internal region, and the 5' region expected to contain the packaging signal are very closely related to members of the ETn subfamily that have recently transposed. Analysis of different mouse strains indicates that MusD elements predate the existence of the mobile subfamily of ETns. These findings indicate that the ETn family was likely created via recombination events resulting in a near complete substitution of MusD coding sequences with unrelated DNA. Furthermore, these results suggest that ETn transcripts retrotranspose using proteins provided by MusD proviruses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.