ArticleArchives of disease in childhood2000
Effect of oral glucocorticoid treatment on serum inflammatory markers in acute asthma.
Article in Archives of disease in childhood, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 64 citations in OpenAlex.
- Efficacy of prednisolone in children hospitalized for recurrent wheezing.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2007Trial
- The combined effects of zafirlukast, prednisone, and inhaled budesonide on IL-13 and IFN-gamma secretion.Journal of clinical immunology · 2005Trial
- Montelukast and fluticasone compared with salmeterol and fluticasone in protecting against asthma exacerbation in adults: one year, double blind, randomised, comparative trial.BMJ (Clinical research ed.) · 2003Trial
- Eosinophil activation and preschool viral wheeze.Thorax · 2003Trial
- Impact of systemic steroids on asthma biomarkers: A comprehensive analysis.The World Allergy Organization journal · 2026Review
- The clinical profile of benralizumab in the management of severe eosinophilic asthma.Therapeutic advances in respiratory disease · 2016Review
- Glucocorticoids increase CD4CD25 cell percentage and Foxp3 expression in patients with multiple sclerosis.Acta neurologica Scandinavica · 2009Article
- Detection of R576 interleukin-4 receptor an allele gene, serum interleukin-4, and eosinophilic cationic protein in atopic dermatitis patients.Indian journal of dermatology · 2009Article
- Persistent airway obstruction after virus infection is not associated with airway inflammation.Chest · 2007Article
- A canine model of cutaneous late-phase reactions: prednisolone inhibition of cellular and cytokine responses.Immunology · 2006Article
- Serum interleukin-5 levels are elevated in mild and moderate persistent asthma irrespective of regular inhaled glucocorticoid therapy.BMC pulmonary medicine · 2004Article
- Use of acetazolamide to decrease cerebrospinal fluid production in chronically ventilated patients with ventriculopleural shunts.Archives of disease in childhood · 2001Article
- Off label and unlicensed drug use among French office based paediatricians.Archives of disease in childhood · 2000Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute asthma is associated with elevated serum concentrations of products of activated T cells and eosinophils.
aimsTo compare the changes in concentrations of these products with disease severity and changes in lung function following oral prednisolone treatment.
methodsTwenty patients (mean age 8.7 years) were recruited on admission with acute asthma to a district general hospital. Disease severity was recorded before and after treatment with oral prednisolone using a validated pulmonary index score. Serum concentrations of interleukin (IL)-4, IL-5, soluble (s)CD25 (soluble IL-2 receptor), using a specific enzyme linked immunosorbent assay, and eosinophil cationic protein (ECP), using radioimmunoassay, were measured concomitantly. Non-asthmatic children (n = 6, mean age 9.2 years) undergoing elective surgery were recruited as controls, and serum samples were obtained on one occasion without treatment. Main outcome measures were changes in serum concentrations of cytokines and ECP, clinical asthma severity score, and peak expiratory flow rate.
resultsAs expected, oral glucocorticoid treatment in the children with asthma was associated with clinical improvement and also with significant reductions in serum concentrations of IL-5 (mean 5.59 to 2.19 pg/ml, p = 0.0001), sCD25 (mean 2236 to 1772 pg/ml, p = 0.002), and ECP (mean 54.3 to 33. 1 pg/ml, p = 0.0001). Serum IL-4 concentrations, in most patients and all the controls, remained below the sensitivity of the assay. However, serum concentrations of IL-5, sCD25, and ECP remained significantly higher than in controls, even after treatment with oral glucocorticoids (p = 0.03).
conclusionsThese data suggest that T cell mediated inflammation may persist in childhood asthma despite apparent clinical remission associated with conventional doses of prednisolone. The long term consequences of persistent inflammation after an apparently treated acute attack of asthma require clarification. Clinical assessment and pulmonary function are inadequate surrogates for airway inflammation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.