ArticleNeurochemical research2000
Rapid and transient learning-associated increase in NMDA NR1 subunit in the rat hippocampus.
Article in Neurochemical research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 57 citations in OpenAlex.
- AMPA Receptor Expression Requirement During Long-Term Memory Retrieval and Its Association with mTORC1 Signaling.Molecular neurobiology · 2021Article
- Does kynurenic acid act on nicotinic receptors? An assessment of the evidence.Journal of neurochemistry · 2020Review
- Nasal Cavity Administration of Melanin-Concentrating Hormone Improves Memory Impairment in Memory-Impaired and Alzheimer's Disease Mouse Models.Molecular neurobiology · 2019Article
- NMDA Receptor Subunits Change after Synaptic Plasticity Induction and Learning and Memory Acquisition.Neural plasticity · 2018Review
- Surface expression of NMDA receptor changes during memory consolidation in the crab Neohelice granulata.Learning & memory (Cold Spring Harbor, N.Y.) · 2016Article
- Very low density lipoprotein receptor regulates dendritic spine formation in a RasGRF1/CaMKII dependent manner.Biochimica et biophysica acta · 2015Article
- Behavioral Tagging: A Translation of the Synaptic Tagging and Capture Hypothesis.Neural plasticity · 2015Review
- The role of protein phosphorylation in the gustatory cortex and amygdala during taste learning.Experimental neurobiology · 2012Article
- Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- The combined effects of exercise and foods in preventing neurological and cognitive disorders.Preventive medicine · 2011Review
- Biological mechanisms of physical activity in preventing cognitive decline.Cellular and molecular neurobiology · 2010Review
- Glutamate transporters are differentially expressed in the hippocampus during the early stages of one-day spatial learning task.Ethnicity & disease · 2010Article
- Review
- Phospholipase A2 activation as a therapeutic approach for cognitive enhancement in early-stage Alzheimer disease.Psychopharmacology · 2009Review
- Conditioning training and retrieval increase phospholipase A(2) activity in the cerebral cortex of rats.Journal of neural transmission (Vienna, Austria : 1996) · 2009Article
- Inhibition of calcium-independent phospholipase A2 activity in rat hippocampus impairs acquisition of short- and long-term memory.Psychopharmacology · 2005Article
- NMDA receptor subunit and CaMKII changes in rat hippocampus induced by acute MDMA treatment: a mechanism for learning impairment.Psychopharmacology · 2004Article
- Gene-environment interplay in affect and dementia: emotional modulation of cognitive expression in personal outcomes.Neurotoxicity research · 2004Article
- Hippocampal glutamate receptors in fear memory consolidation.Neurotoxicity research · 2004Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several lines of evidence indicate that glutamate NMDA receptors are critically involved in long-term potentiation (LTP) and in certain forms of learning. It was previously demonstrated that memory formation of an inhibitory avoidance task in chick is specifically associated with an increase in the density of NMDA receptor in selected brain regions. Here we report on the effect of a one trial inhibitory avoidance training in rats, a hippocampal-dependent learning task, on the levels of different subunits of the glutamate NMDA receptor in synaptic plasma membranes (SPM) isolated from the hippocampus. Training rats on a one trial inhibitory avoidance task results in a rapid, transient and selective increase (+33%, p < 0.05) in NMDA NRI subunit expression in hippocampal SPM of rats sacrificed 30 min posttraining. No changes were observed at 0 or 120 min after training or in shocked animals in comparison to naive control rats. In addition, no training-associated increase in the levels of NMDA NR2A and NR2B or AMPA GluR 2/3 subunits was observed at any timepoint tested. In conclusion, the present findings support the hypothesis that alterations in expression of synaptic NMDA NR1 subunits in the hippocampus are specifically associated with memory formation of an inhibitory avoidance task and strongly suggest that hippocampal NMDA receptors are crucially involved in the neural mechanisms underlying certain forms of learning.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.