Evidence map›Paper›PMID 10904452›Full record

SynthesisArchives of internal medicine2000

Depression is a risk factor for noncompliance with medical treatment: meta-analysis of the effects of anxiety and depression on patient adherence.

M R DiMatteo, H S Lepper, T W Croghan

7 registry-linked trialsAbstract readComparative StudyMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Archives of internal medicine, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 7 registered trials, which are not on this map. Cited by 1,441 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1,441citing papers in PubMed, 13 pooled it
68.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01321255 phase3completedstarted 2012, after this paper: background citation

Improving Equitable Acces and Adherence to Secondary Prevention Therapy With a Fixed-Dose Combination Drug

Ran2012Enrolled2,118Registered outcomes6Posted comparisons0ConditionsMyocardial InfarctionArmsFDC, Separately drugs, simvastatin, aspirin and ramipril
PMID 16603580PMID 17378996PMID 18288541PMID 16462975PMID 18775238PMID 11293642PMID 11556941PMID 11786451PMID 12027289PMID 12813116PMID 12829553PMID 12829554other papers from this trial
Open the trial in the graph
NCT02783430 phase2 / phase3completednot on this mapstarted 2016, after this paper: background citation

Evaluation of the Initial Prescription of Ketamine and Milnacipran Forin Depression in Patients With a Progressive Disease

TypeinterventionalSponsorUniversity Hospital, LilleRan2016 to 2024Enrolled42ConditionsDepressionArmsKetamine, Milnacipran, Placebo
NCT03092479 nacompletednot on this mapstarted 2017, after this paper: background citation

A Randomized Trial of a Pilot Behavioral Support Intervention After Bariatric Surgery

TypeinterventionalSponsorGeisinger ClinicRan2017 to 2017Enrolled50ConditionsObesityArmsBehavioral Intervention
NCT03336827 nacompletednot on this mapstarted 2017, after this paper: background citation

Improving Emotion Regulation at the End of Breast Cancer Treatment: A Randomized Controlled Study Assessing the Impact of a Multi-Component Psychological Group Intervention

TypeinterventionalSponsorUniversité Libre de BruxellesRan2017 to 2020Enrolled120ConditionsBreast Cancer, Emotional Disturbances, Emotional Dysfunction, Anxiety DepressionArmsCognitive-Behavioral Group Therapy and Hypnosis
NCT05450822 recruitingnot on this mapstarted 2022, after this paper: background citation

The BrainDrugs-Epilepsy Study: A Prospective Open-label Cohort Precision Medicine Study in Epilepsy

TypeobservationalSponsorGitte Moos KnudsenRan2022 to 2031Enrolled550ConditionsEpilepsyArmsLevetiracetam, Levetiracetam Tablets, Lamotrigine tablet
NCT05774002 narecruitingnot on this mapstarted 2023, after this paper: background citation

Psychological Assessment of Scoliosis Patients Undergoing Surgical Management (PASS)

TypeinterventionalSponsorMontefiore Medical CenterRan2023 to 2028Enrolled120ConditionsAdolescent Idiopathic Scoliosis (AIS), Mental HealthArmsAims to Decrease Anxiety and Pain Treatment (ADAPT)
NCT06587555 not yet recruitingnot on this mapstarted 2024, after this paper: background citation

Correlations Between Symptoms of Anxiety And/or Depression with Dysphagia Severity Level

Typeobservational_patient_registrySponsorUniversitas PadjadjaranRan2024 to 2025Enrolled30ConditionsDysphagia, Anxiety, Depression
3 · Its place in the literature

Who cites it

1,441 citing papers in PubMed, 13 syntheses or guidelines pooled it, 4,123 citations in OpenAlex.

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1,381 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

M R DiMatteoDepartment of Psychology, University of California, Riverside, CA 92521, USA. robin@citrus.ucr.edu
H S Lepper
T W Croghan
Drake University · USEli Lilly (United States) · USUniversity of California, Riverside · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDepression and anxiety are common in medical patients and are associated with diminished health status and increased health care utilization. This article presents a quantitative review and synthesis of studies correlating medical patients' treatment noncompliance with their anxiety and depression.

methodsResearch on patient adherence catalogued on MEDLINE and PsychLit from January 1, 1968, through March 31, 1998, was examined, and studies were included in this review if they measured patient compliance and depression or anxiety (with n>10); involved a medical regimen recommended by a nonpsychiatrist physician to a patient not being treated for anxiety, depression, or a psychiatric illness; and measured the relationship between patient compliance and patient anxiety and/or depression (or provided data to calculate it).

resultsTwelve articles about depression and 13 about anxiety met the inclusion criteria. The associations between anxiety and noncompliance were variable, and their averages were small and nonsignificant. The relationship between depression and noncompliance, however, was substantial and significant, with an odds ratio of 3.03 (95% confidence interval, 1.96-4.89).

conclusionsCompared with nondepressed patients, the odds are 3 times greater that depressed patients will be noncompliant with medical treatment recommendations. Recommendations for future research include attention to causal inferences and exploration of mechanisms to explain the effects. Evidence of strong covariation of depression and medical noncompliance suggests the importance of recognizing depression as a risk factor for poor outcomes among patients who might not be adhering to medical advice.

Indexed as

Health StatusOutcome Assessment, Health CareTreatment RefusalAdultAnxietyArthritis, RheumatoidDepressionHumansKidney Failure, ChronicNeoplasmsOdds RatioPatient ComplianceRetrospective StudiesRisk FactorsSurveys and Questionnaires

Identifiers

PMID10904452
OpenAlexW2123277906

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 1 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.