SynthesisBMJ (Clinical research ed.)2000
Chlamydia pneumoniae IgG titres and coronary heart disease: prospective study and meta-analysis.
Synthesis in BMJ (Clinical research ed.), 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Antibiotics for secondary prevention of coronary heart disease.The Cochrane database of systematic reviews · 2021Pooled it
- A meta-analysis of antibiotic use for the secondary prevention of cardiovascular diseases.The Canadian journal of cardiology · 2008Pooled it
- Association of circulating Chlamydia pneumoniae DNA with cardiovascular disease: a systematic review.BMC infectious diseases · 2002Pooled it
- Antibody levels against Chlamydia pneumoniae and outcome of roxithromycin therapy in patients with acute myocardial infarction. Results from a sub-study of the randomised Antibiotic Therapy in Acute Myocardial Infarction (ANTIBIO) trial.Zeitschrift fur Kardiologie · 2004Trial
- Article
- Chlamydia pneumoniae Seropositivity is Associated with Cardiovascular Events in the General Population: The Nagahama Study.Journal of atherosclerosis and thrombosis · 2026Article
- Viridans Streptococcal Biofilm Evades Immune Detection and Contributes to Inflammation and Rupture of Atherosclerotic Plaques.Journal of the American Heart Association · 2025Article
- Cardiovascular benefits and safety profile of macrolide maintenance therapy in patients with bronchiectasis.The European respiratory journal · 2025Article
- Invited Commentary: The Microbiome and Population Health-Considerations for Enhancing Study Design and Data Analysis in Observational and Interventional Epidemiology.American journal of epidemiology · 2018Article
- An Unsettled Debate About the Potential Role of Infection in Pathogenesis of Atherosclerosis.Journal of clinical medicine research · 2017Review
- Chlamydophila pneumoniae infection and cardiovascular disease.North American journal of medical sciences · 2013Article
- Early cardiac allograft vasculopathy: are the viruses to blame?Case reports in medicine · 2012Article
- Pathogen burden, cytomegalovirus infection and inflammatory markers in the risk of premature coronary artery disease in individuals of Indian origin.Experimental and clinical cardiology · 2012Article
- Prognostic effect size of cardiovascular biomarkers in datasets from observational studies versus randomised trials: meta-epidemiology study.BMJ (Clinical research ed.) · 2011Review
- Salivary immunoglobulins and prevalent coronary artery disease.Journal of dental research · 2010Article
- Mycoplasma pneumoniae and/or Chlamydophila pneumoniae inoculation causing different aggravations in cholesterol-induced atherosclerosis in apoE KO male mice.BMC microbiology · 2009Article
- Socioeconomic position and inflammatory and immune biomarkers of cardiovascular disease: applications to the Panel Study of Income Dynamics.Biodemography and social biology · 2009Review
- Article
- The effect of Chlamydia pneumoniae on the expression of peroxisome proliferator-activated receptor-gamma in vascular smooth muscle cells.Yonsei medical journal · 2008Article
- Limited role for C. pneumoniae, CMV and HSV-1 in cerebral large and small vessel atherosclerosis.The open neurology journal · 2008Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine the association between coronary heart disease and serum markers of chronic Chlamydia pneumoniae infection.
design"Nested" case-control analysis in a prospective cohort study and an updated meta-analysis of previous relevant studies.
settingGeneral practices in 18 towns in Britain.
participantsOf the 5661 men aged 40-59 who provided blood samples during 1978-80, 496 men who died from coronary heart disease or had non-fatal myocardial infarction and 989 men who had not developed coronary heart disease by 1996 were included.
main outcome measuresIgG serum antibodies to C pneumoniae in baseline samples; details of fatal and non-fatal coronary heart disease from medical records and death certificates.
results200 (40%) of the 496 men with coronary heart disease were in the top third of C pneumoniae titres compared with 329 (33%) of the 989 controls. The corresponding odds ratio for coronary heart disease was 1.66 (95% confidence interval 1.25 to 2.21), which fell to 1.22 (0.82 to 1.82) after adjustment for smoking and indicators of socioeconomic status. No strong associations were observed between C pneumoniae IgG titres and blood lipid concentrations, blood pressure, or plasma homocysteine concentration. In aggregate, the present study and 14 other prospective studies of C pneumoniae IgG titres included 3169 cases, yielding a combined odds ratio of 1. 15 (0.97 to 1.36), with no significant heterogeneity among the separate studies (chi(2)=10.5, df=14; P>0.1).
conclusionThis study, together with a meta-analysis of previous prospective studies, reliably excludes the existence of any strong association between C pneumoniae IgG titres and incident coronary heart disease. Further studies are required, however, to confirm or refute any modest association that may exist, particularly at younger ages.
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