ArticleBMJ (Clinical research ed.)2000
Chlamydia pneumoniae infection and mortality from ischaemic heart disease: large prospective study.
Article in BMJ (Clinical research ed.), 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 78 citations in OpenAlex.
- Chlamydia pneumoniae IgG titres and coronary heart disease: prospective study and meta-analysis.BMJ (Clinical research ed.) · 2000Pooled it
- Chlamydophila pneumoniae infection and cardiovascular disease.North American journal of medical sciences · 2013Article
- Intranasal immunization strategy to impede pilin-mediated binding of Pseudomonas aeruginosa to airway epithelial cells.Infection and immunity · 2005Article
- Ectasia and severe atherosclerosis: relationships with chlamydia pneumoniae, helicobacterpylori, and inflammatory markers.Texas Heart Institute journal · 2005Article
- Measurement of Chlamydia pneumoniae-specific immunoglobulin A (IgA) antibodies by the microimmunofluorescence (MIF) method: comparison of seven fluorescein-labeled anti-human IgA conjugates in an in-house MIF test using one commercial MIF and one enzyme immunoassay kit.Clinical and diagnostic laboratory immunology · 2003Article
- Parachlamydiaceae: potential emerging pathogens.Emerging infectious diseases · 2002Review
- Role of infectious and immune factors in coronary and cerebrovascular arteriosclerosis.Clinical and diagnostic laboratory immunology · 2002Review
- Chlamydia pneumoniae in infrequently examined blood vessels.Journal of clinical pathology · 2002Article
- Development and evaluation of real-time PCR-based fluorescence assays for detection of Chlamydia pneumoniae.Journal of clinical microbiology · 2002Article
- Chlamydia pneumoniae and atherosclerosis: critical assessment of diagnostic methods and relevance to treatment studies.Clinical microbiology reviews · 2002Review
- Mutagenesis and functional reconstitution of chlamydial major outer membrane proteins: VS4 domains are not required for pore formation but modify channel function.Infection and immunity · 2001Article
- Bacterial lipopolysaccharide and tumor necrosis factor alpha synergistically increase expression of human endothelial adhesion molecules through activation of NF-kappaB and p38 mitogen-activated protein kinase signaling pathways.Infection and immunity · 2001Article
- Heart disease and the inflammatory response.BMJ (Clinical research ed.) · 2000Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine whether there is an independent association between infection with Chlamydia pneumoniae and ischaemic heart disease.
designProspective study using a nested case-control design.
settingMedical centre in London run by BUPA, a private medical organisation.
participants21 520 professional men aged 35-64 who attended for a medical examination in London between 1975 and 1982.
main outcome measureDeath from ischaemic heart disease.
resultsThe distributions of concentrations of IgG and IgA antibodies to C pneumoniae were similar in the 647 men who subsequently died of ischaemic heart disease and in 1294 age matched controls who did not. There was no material association with heart disease irrespective of the cut-off point chosen to define seropositivity. At a cut-off point that defines 15% of controls as positive, for example, the odds ratios were 1.26 (95% confidence interval 0.95 to 1.68) for IgG and 1.09 (0.82 to 1.43) for IgA.
conclusionsNo material association was found between infection with C pneumoniae and ischaemic heart disease. The size and prospective design of the study and the socioeconomic homogeneity of the cohort minimise both random and systematic error.
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