ArticleThe Journal of clinical investigation2000
Erythroid progenitors differentiate and mature in response to endogenous erythropoietin.
Article in The Journal of clinical investigation, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 80 citations in OpenAlex.
- Survival and erythropoietin receptor protein in tumours from patients randomly treated with rhEPO for palliative care.Medical oncology (Northwood, London, England) · 2008Trial
- Review
- Recent updates of stem cell-based erythropoiesis.Human cell · 2023Review
- Optimal glycated hemoglobin A1c value for prediabetes and diabetes in patients with pancreatic diseases.Frontiers in endocrinology · 2023Article
- IL-6 blockade reverses bone marrow failure induced by human acute myeloid leukemia.Science translational medicine · 2020Article
- Recovery of Pure Red Cell Aplasia Following Hematopoietic Stem Cell Transplantation Associated with Interleukin (IL)-6 Elevation Caused by Odontogenic Infection.Internal medicine (Tokyo, Japan) · 2018Article
- Zinc Supplementation Stimulates Red Blood Cell Formation in Rats.International journal of molecular sciences · 2018Article
- Erythropoietin enhances migration of human neuroblastoma cells: in vitro studies and potential therapeutic implications.Journal of cancer stem cell research · 2017Article
- Erythropoietin stimulates the coronary collateral development in patients with coronary chronic total occlusion.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2016Article
- Effect of Erythropoietin on Postresuscitation Renal Function in a Swine Model of Ventricular Fibrillation.BioMed research international · 2016Article
- The Local HIF-2α/EPO Pathway in the Bone Marrow is Associated with Excessive Erythrocytosis and the Increase in Bone Marrow Microvessel Density in Chronic Mountain Sickness.High altitude medicine & biology · 2015Article
- Activation of mitochondrial function and Hb expression in non-haematopoietic cells by an EPO inducer ameliorates ischaemic diseases in mice.British journal of pharmacology · 2013Article
- Endothelial progenitor cell: a blood cell by many other names may serve similar functions.Journal of molecular medicine (Berlin, Germany) · 2013Review
- Overexpression of the toll-like receptor (TLR) signaling adaptor MYD88, but lack of genetic mutation, in myelodysplastic syndromes.PloS one · 2013Article
- Red ginseng deregulates hypoxia-induced genes by dissociating the HIF-1 dimer.Journal of natural medicines · 2011Article
- Article
- Article
- Therapeutic potential of erythropoietin in cardiovascular disease: erythropoiesis and beyond.Current heart failure reports · 2007Review
- Osteoblast autonomous Pi regulation via Pit1 plays a role in bone mineralization.Molecular and cellular biology · 2007Article
- TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors.Leukemia · 2002Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We reported previously that stimulation of glycoprotein 130 (gp130) by a combination of human IL-6 and soluble IL-6 receptor (sIL-6R) could support proliferation, differentiation, and terminal maturation of erythroid cells in the absence of erythropoietin (EPO) from human CD34(+) cells in culture with stem cell factor (SCF). This observation suggested that differentiation of hematopoietic stem/progenitor cells to erythroid cells progressed according to an intrinsic program and that EPO receptor (EPOR) could be replaced by other cytokine receptors. In other words, EPOR appeared to be dispensable for erythropoiesis. Here we examined the role of EPOR in erythropoiesis stimulated by SCF, sIL-6R, and IL-6. Surprisingly, reduction of EPOR expression using antisense oligodeoxynucleotides suppressed erythropoiesis stimulated not only by SCF and EPO, but also by SCF, sIL-6R, and IL-6. EPO mRNA was detected in erythroid cells but not myeloid cells cultured in the presence of SCF, sIL-6R, and IL-6. Furthermore, high concentrations of anti-EPO-neutralizing antibody abrogated erythropoiesis in cultures without exogenous EPO. Based on these results, we suggest that erythroid progenitors themselves secrete EPO and that they have the potential to differentiate and mature in response to this endogenous EPO.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.