ArticleThe Journal of clinical investigation2000
Systemically derived large intestinal CD4(+) Th2 cells play a central role in STAT6-mediated allergic diarrhea.
Article in The Journal of clinical investigation, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
52 citing papers in PubMed, 163 citations in OpenAlex.
- Primary Eosinophilic Colitis Manifesting As Acute Appendicitis: A Case Report and Literature Review.Cureus · 2025Article
- Evaluation of the Impact of BaP Exposure on the Gut Microbiota and Allergic Responses in an OVA-Sensitized Mouse Model.Environmental health perspectives · 2023Article
- IL-4 receptor alpha signaling alters oral food challenge and immunotherapy outcomes in mice.The Journal of allergy and clinical immunology · 2023Article
- Effects of the loss of maternal gut microbiota before pregnancy on gut microbiota, food allergy susceptibility, and epigenetic modification on subsequent generations.Bioscience of microbiota, food and health · 2023Article
- Bisdemethoxycurcumin attenuates OVA-induced food allergy by inhibiting the MAPK and NF-κB signaling pathways.Experimental and therapeutic medicine · 2022Article
- Orally desensitized mast cells form a regulatory network with Treg cells for the control of food allergy.Mucosal immunology · 2021Article
- Anaphylaxis induced by Thalassophryne nattereri venom in mice is an IgE/IgG1-mediated, IL-4-dependent phenomenon.Scientific reports · 2020Article
- Deletion of ΔdblGata motif leads to increased predisposition and severity of IgE-mediated food-induced anaphylaxis response.PloS one · 2019Article
- Nonesophageal Eosinophilic Gastrointestinal Disorders: Clinical Care and Future Directions.Journal of pediatric gastroenterology and nutrition · 2018Review
- Autoimmunity and intestinal colonization by Candida albicans in patients with type 1 diabetes at the time of the diagnosis.Korean journal of pediatrics · 2018Article
- Food-Induced Acute Pancreatitis.Digestive diseases and sciences · 2017Review
- A humanized mouse model of anaphylactic peanut allergy.The Journal of allergy and clinical immunology · 2017Article
- Regulation of IgE-Mediated Food Allergy by IL-9 Producing Mucosal Mast Cells and Type 2 Innate Lymphoid Cells.Immune network · 2016Review
- STAT6 and PARP Family Members in the Development of T Cell-dependent Allergic Inflammation.Immune network · 2016Review
- Eosinophilic colitis.BMJ case reports · 2016Article
- Pacific oyster-derived polysaccharides attenuate allergen-induced intestinal inflammation in a murine model of food allergy.Journal of food and drug analysis · 2016Article
- Induction of Interleukin-9-Producing Mucosal Mast Cells Promotes Susceptibility to IgE-Mediated Experimental Food Allergy.Immunity · 2015Article
- Dietary ω3 fatty acid exerts anti-allergic effect through the conversion to 17,18-epoxyeicosatetraenoic acid in the gut.Scientific reports · 2015Article
- Microscopic colitis (lymphocytic and collagenous), eosinophilic colitis, and celiac disease.Clinics in colon and rectal surgery · 2015Review
- New era for mucosal mast cells: their roles in inflammation, allergic immune responses and adjuvant development.Experimental & molecular medicine · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systemically primed BALB/c mice developed severe diarrhea after repeated oral administration of ovalbumin (OVA). Histological analysis demonstrated that dramatic infiltration of eosinophils and mast cells occurred in the large intestine but not in the small intestine of mice with diarrhea. Interestingly, CD4(+) alphabeta T cells of the large intestine secreted IL-4 and IL-13 at high levels. Identically treated STAT6 gene-disrupted mice failed to develop OVA-induced diarrhea. Further, treatment of BALB/c mice with monoclonal anti-IL-4 antibody prevented the development of allergic diarrhea. An adoptive transfer study showed that systemically primed splenic CD4(+) T cells were preferentially recruited into the large intestine upon exposure to oral OVA. These results strongly suggest that systemically derived CD4(+) alphabeta T cells of the large intestine play a critical role in the onset of Th2-mediated intestinal allergic disorders via STAT6 signal transduction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.