ArticleBritish journal of cancer2000
Immunohistochemical detection of membrane-type-1-matrix metalloproteinase in colorectal carcinoma.
Article in British journal of cancer, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 48 citations in OpenAlex.
- The differential cancer growth associated with anaesthetics in a cancer xenograft model of mice: mechanisms and implications of postoperative cancer recurrence.Cell biology and toxicology · 2023Article
- Comprehensive Analysis of the Expression and Prognosis for MMPs in Human Colorectal Cancer.Frontiers in oncology · 2021Article
- Strong association of tissue inhibitor of metalloproteinase (TIMP)-2 and -3 promoter single nucleotide polymorphisms with risk of colorectal cancer in ethnic Kashmiri population - a case control study.Bioscience reports · 2019Article
- Targeting the MMP-14/MMP-2/integrin αThe Journal of biological chemistry · 2018Article
- May High MMP-2 and TIMP-2 Expressions Increase or Decrease the Aggressivity of Oral Cancer?Pathology oncology research : POR · 2017Article
- LIN28 cooperates with WNT signaling to drive invasive intestinal and colorectal adenocarcinoma in mice and humans.Genes & development · 2015Article
- Immunoexpression of metalloproteinases 2 and 14 and TIMP-2 inhibitor in main types of primary gastric carcinomas and lymph node metastasis.Pathology oncology research : POR · 2015Article
- Lack of Association between Membrane-Type 1 Matrix Metalloproteinase Expression and Clinically Relevant Molecular or Morphologic Tumor Characteristics at the Leading Edge of Invasive Colorectal Carcinoma.BioMed research international · 2015Article
- Correlation between the expression of the BAG-1 gene and clinicopathologic factors in colorectal cancer.Journal of cancer research and clinical oncology · 2011Article
- Active matrix metalloproteinase-2 activity discriminates colonic mucosa, adenomas with and without high-grade dysplasia, and cancers.Human pathology · 2011Article
- New Strategies for the Next Generation of Matrix-Metalloproteinase Inhibitors: Selectively Targeting Membrane-Anchored MMPs with Therapeutic Antibodies.Biochemistry research international · 2011Article
- Cell surface markers in colorectal cancer prognosis.International journal of molecular sciences · 2010Review
- Immunohistochemically detected high expression of matrix metalloproteinase-2 as predictor of poor prognosis in Duke's B colon cancer.Croatian medical journal · 2008Article
- Tissue inhibitor of matrix metalloproteinase-2 in nasopharyngeal carcinoma.MedGenMed : Medscape general medicine · 2007Article
- Clinicopathologic and prognostic significance of matrix metalloproteinases in rectal cancer.International journal of colorectal disease · 2007Article
- Simultaneous determination of matrix metalloproteinase (MMP)-7, MMP-1, -3, and -13 gene expression by multiplex PCR in colorectal carcinomas.International journal of colorectal disease · 2004Article
- Article
- Matrix metalloproteinases 2 and 9 (gelatinases A and B) expression in malignant mesothelioma and benign pleura.British journal of cancer · 2003Article
- Nuclear BAG-1 expression reflects malignant potential in colorectal carcinomas.British journal of cancer · 2002Article
- Matrix metalloproteinase 13 activity is associated with poor prognosis in colorectal cancer.Journal of clinical pathology · 2002Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated whether the expression of membrane-type-1 matrix metalloproteinase (MT1-MMP), matrix metalloproteinase-2 (MMP-2) and tissue inhibitor of metalloproteinase-2 (TIMP-2) was consistent with the proposed roles of these proteins in promoting metastasis in colorectal cancer. The expression of MT1-MMP was significantly more frequent in deeply invasive carcinomas (P = 0.007) and in cases of vascular invasion (P = 0.02). The frequency of detection of MMP-2 in the stroma was much greater in vascular invasion-positive cases (42%) than in negative cases (20%; P = 0.02). The rate of detection of TIMP-2 in tumour cell cytoplasm increased with the depth of invasion (P = 0.03). TIMP-2 in the stroma was found more frequently in tumours with lymphatic invasion and lymph node metastasis (P < 0.05). Significant correlations were found between detection of MT1-MMP and MMP-2 in tumour cell cytoplasm (P < 0.05), of MT1-MMP and TIMP-2 in tumour cell cytoplasm (P < 0.01), and of MMP-2 and TIMP-2 in tumour cell cytoplasm (P < 0.01). Immunohistochemical detection of MT1-MMP and TIMP-2 might be useful for monitoring infiltration in colorectal carcinoma but is not correlated with distant metastases.
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