ArticleProceedings of the National Academy of Sciences of the United States of America2000
Calcium imaging demonstrates colocalization of calcium influx and extrusion in fly photoreceptors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Insights into tick-pathogen interactions - a single cell RNA sequencing approach of transcriptional changes during ehrlichial infection.bioRxiv : the preprint server for biology · 2026Article
- Calcium signalling in Drosophila photoreceptors measured with GCaMP6f.Cell calcium · 2017Article
- Fractional Ca(2+) currents through TRP and TRPL channels in Drosophila photoreceptors.Biophysical journal · 2013Article
- Compartmentalization and Ca2+ buffering are essential for prevention of light-induced retinal degeneration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Phospholipase C-mediated suppression of dark noise enables single-photon detection in Drosophila photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Calnexin is essential for rhodopsin maturation, Ca2+ regulation, and photoreceptor cell survival.Neuron · 2006Article
- Insights on TRP channels from in vivo studies in Drosophila.Annual review of physiology · 2006Review
- Light dependence of oxygen consumption by blowfly eyes recorded with a magnetic diver balance.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2005Article
- Shaker K(+)-channels are predicted to reduce the metabolic cost of neural information in Drosophila photoreceptors.Proceedings. Biological sciences · 2003Article
- Ion fluxes and cytosolic pool sizes: examining fundamental relationships in transmembrane flux regulation.Planta · 2003Review
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
During illumination, Ca(2+) enters fly photoreceptor cells through light-activated channels that are located in the rhabdomere, the compartment specialized for phototransduction. From the rhabdomere, Ca(2+) diffuses into the cell body. We visualize this process by rapidly imaging the fluorescence in a cross section of a photoreceptor cell injected with a fluorescent Ca(2+) indicator in vivo. The free Ca(2+) concentration in the rhabdomere shows a very fast and large transient shortly after light onset. The free Ca(2+) concentration in the cell body rises more slowly and displays a much smaller transient. After approximately 400 ms of light stimulation, the Ca(2+) concentration in both compartments reaches a steady state, indicating that thereafter an amount of Ca(2+), equivalent to the amount of Ca(2+) flowing into the cell, is extruded. Quantitative analysis demonstrates that during the steady state, the free Ca(2+) concentration in the rhabdomere and throughout the cell body is the same. This shows that Ca(2+) extrusion takes place very close to the location of Ca(2+) influx, the rhabdomere, because otherwise gradients in the steady-state distribution of Ca(2+) should be measured. The close colocalization of Ca(2+) influx and Ca(2+) extrusion ensures that, after turning off the light, Ca(2+) removal from the rhabdomere is faster than from the cell body. This is functionally significant because it ensures rapid dark adaptation.
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