ArticleProceedings of the National Academy of Sciences of the United States of America2000
The serine and threonine residues in the Ig-alpha cytoplasmic tail negatively regulate immunoreceptor tyrosine-based activation motif-mediated signal transduction.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Dectin-1 intracellular domain determines species-specific ligand spectrum by modulating receptor sensitivity.The Journal of biological chemistry · 2017Article
- Reconstituted B cell receptor signaling reveals carbohydrate-dependent mode of activation.Scientific reports · 2016Article
- In vitro reconstitution of B cell receptor-antigen interactions to evaluate potential vaccine candidates.Nature protocols · 2016Article
- Structural and genetic basis for development of broadly neutralizing influenza antibodies.Nature · 2012Article
- The mouse B cell-specific mb-1 gene encodes an immunoreceptor tyrosine-based activation motif (ITAM) protein that may be evolutionarily conserved in diverse species by purifying selection.Molecular biology reports · 2012Article
- Cytoplasmic Ig alpha serine/threonines fine-tune Ig alpha tyrosine phosphorylation and limit bone marrow plasma cell formation.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Syk is a dual-specificity kinase that self-regulates the signal output from the B-cell antigen receptor.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- The safety on the TCR trigger.Cell · 2008Article
- Ig beta tyrosine residues contribute to the control of B cell receptor signaling by regulating receptor internalization.The Journal of experimental medicine · 2006Article
- Ligand-independent signaling during early avian B cell development.Immunologic research · 2006Review
- B-cell antigen-receptor signalling in lymphocyte development.Immunology · 2003Review
- Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a).Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- The direct recruitment of BLNK to immunoglobulin alpha couples the B-cell antigen receptor to distal signaling pathways.Molecular and cellular biology · 2002Article
- Ligand-independent signaling functions for the B lymphocyte antigen receptor and their role in positive selection during B lymphopoiesis.The Journal of experimental medicine · 2001Article
- Interference with immunoglobulin (Ig)alpha immunoreceptor tyrosine-based activation motif (ITAM) phosphorylation modulates or blocks B cell development, depending on the availability of an Igbeta cytoplasmic tail.The Journal of experimental medicine · 2001Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The B cell antigen receptor (BCR) is a multiprotein complex consisting of the membrane-bound Ig molecule and the Ig-alpha/Ig-beta heterodimer. On BCR engagement, Ig-alpha and Ig-beta become phosphorylated not only on tyrosine residues of the immunoreceptor tyrosine-based activation motif but also on serine and threonine residues. We have mutated all serine and threonine residues in the Ig-alpha tail to alanine and valine, respectively. The mutated Ig-alpha sequence was expressed either as a single-chain Fv/Ig-alpha molecule or in the context of the complete BCR. In both cases, the mutated Ig-alpha showed a stronger tyrosine phosphorylation than the wild-type Ig-alpha and initiated increased signaling on stimulation. These findings suggest that serine/threonine kinases can negatively regulate signal transduction from the BCR.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.