ArticleInfection and immunity2000
Down-regulation of GATA-2 transcription during Pneumocystis carinii infection.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Role of the pioneer transcription factor GATA2 in health and disease.Journal of molecular medicine (Berlin, Germany) · 2023Review
- Pulmonary Manifestations of GATA2 Deficiency.Chest · 2021Article
- CISH attenuates homeostatic cytokine signaling to promote lung-specific macrophage programming and function.Science signaling · 2021Article
- Efferocytic Defects in Early Atherosclerosis Are Driven by GATA2 Overexpression in Macrophages.Frontiers in immunology · 2020Article
- Cancers Related to Immunodeficiencies: Update and Perspectives.Frontiers in immunology · 2016Review
- GATA2 deficiency in children and adults with severe pulmonary alveolar proteinosis and hematologic disorders.BMC pulmonary medicine · 2015Article
- Pneumocystis workshop: 10th anniversary summary.Eukaryotic cell · 2009Article
- Effect of bronchoalveolar lavage fluid from Pneumocystis carinii-infected hosts on phagocytic activity of alveolar macrophages.Infection and immunity · 2004Article
- Effect of transcription factor GATA-2 on phagocytic activity of alveolar macrophages from Pneumocystis carinii-infected hosts.Infection and immunity · 2003Article
- Correlation of organism burden and alveolar macrophage counts during infection with Pneumocystis carinii and recovery.Clinical and diagnostic laboratory immunology · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Differences in gene expression between Pneumocystis carinii-infected and noninfected rats were examined. Total RNA was isolated from homogenized rat lungs and then subjected to differential display with combinations of oligo(dT) and various arbitrary PCR primers. Approximately 50 differentially expressed bands were observed. Several of these DNA bands were isolated, reamplified, and cloned. The cloned DNA fragments were used as probes to perform Northern hybridization on RNA from P. carinii-infected and noninfected rat lungs. One clone was found to react with a 3-kb mRNA from noninfected but not from P. carinii-infected rat lung, suggesting that the gene represented by this clone was down-regulated during P. carinii infection. The nucleotide sequence of this clone was determined and found to be 97% homologous to the mouse GATA-2 transcription factor. In situ hybridization using RNA probes derived from this clone revealed that alveolar macrophages, resident lung monocytes, and bronchial epithelial cells express the GATA-2 gene in the lung.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.