ArticleInsect biochemistry and molecular biology2000
Novel point mutations in the German cockroach para sodium channel gene are associated with knockdown resistance (kdr) to pyrethroid insecticides.
Article in Insect biochemistry and molecular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 85 citations in OpenAlex.
- Exploring and Mitigating Insecticide Resistance in Urban Pests with New Synergists and Insecticides.Insects · 2026Review
- Article
- Susceptibility Status of Several Field-Collected German Cockroaches (Iranian journal of public health · 2024Article
- Transcriptomics analysis of ethanol treatment of maleFrontiers in physiology · 2023Article
- Detection of pyrethroids resistance alleles in goat biting louseVeterinary research forum : an international quarterly journal · 2023Article
- Article
- Pyrethroids resistance inVeterinary research forum : an international quarterly journal · 2022Article
- Low Levels of Pyrethroid Resistance in Hybrid Offspring of a Highly Resistant and a More Susceptible Mosquito Strain.Journal of insect science (Online) · 2020Article
- Pervasive Resistance to Pyrethroids in German Cockroaches (Blattodea: Ectobiidae) Related to Lack of Efficacy of Total Release Foggers.Journal of economic entomology · 2019Article
- Review
- Insecticide resistance and its molecular basis in urban insect pests.Parasitology research · 2016Review
- A mutation in the intracellular loop III/IV of mosquito sodium channel synergizes the effect of mutations in helix IIS6 on pyrethroid resistance.Molecular pharmacology · 2015Article
- Sodium channel point mutations associated with pyrethroid resistance in Chinese strains of Culex pipiens quinquefasciatus (Diptera: Culicidae).Parasites & vectors · 2014Article
- Molecular biology of insect sodium channels and pyrethroid resistance.Insect biochemistry and molecular biology · 2014Article
- Article
- The molecular genetics of insecticide resistance.Genetics · 2013Review
- Diversity and Convergence of Sodium Channel Mutations Involved in Resistance to Pyrethroids.Pesticide biochemistry and physiology · 2013Article
- Distribution patterns of three sodium channel mutations associated with pyrethroid resistance in Rhipicephalus (Boophilus) microplus populations from North and South America, South Africa and Australia.International journal for parasitology. Drugs and drug resistance · 2012Article
- Adaptive evolution of voltage-gated sodium channels: the first 800 million years.Proceedings of the National Academy of Sciences of the United States of America · 2012Review
- Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Knockdown resistance (kdr) to pyrethroid insecticides has been attributed to point mutations in the para sodium channel gene in more than a half dozen insect pest species. In this study, we identified two novel para mutations in five highly resistant kdr-type German cockroach strains. The two mutations, from glutamic acid (E434) to lysine (K434) and from cysteine (C764) to arginine (R764), respectively, are located in the first intracellular linker connecting domains I and II. E434K is located near the beginning of the linker (closest to domain I), whereas C764R is found toward the end of the linker (closest to domain II). Two additional mutations from aspartic acid (D58) to glycine (G58), and from proline (P1880) to leucine (L1888), respectively, were found in one of the resistant strains. The four mutations coexist with the previously identified leucine to phenylalanine (L993F) kdr mutation in IIS6, and are present only in the highly resistant individuals of a given strain. These findings suggest that these mutations might be responsible for high levels of knockdown resistance toward pyrethroid insecticides in the German cockroach.
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