ArticleGenome research2000
Distribution of hammerhead and hammerhead-like RNA motifs through the GenBank.
Article in Genome research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Identification of Hammerhead-variant ribozyme sequences in SARS-CoV-2.Nucleic acids research · 2024Article
- G17-modified hammerhead ribozymes are active in vitro and in vivo.RNA (New York, N.Y.) · 2013Article
- Bridging the gap between theory and experiment to derive a detailed understanding of hammerhead ribozyme catalysis.Progress in molecular biology and translational science · 2013Review
- The ubiquitous hammerhead ribozyme.RNA (New York, N.Y.) · 2012Review
- Identification of hammerhead ribozymes in all domains of life reveals novel structural variations.PLoS computational biology · 2011Article
- Structure-based search reveals hammerhead ribozymes in the human microbiome.The Journal of biological chemistry · 2011Article
- Ubiquitous presence of the hammerhead ribozyme motif along the tree of life.RNA (New York, N.Y.) · 2010Article
- Computational discovery of folded RNA domains in genomes and in vitro selected libraries.Methods (San Diego, Calif.) · 2010Review
- Small self-cleaving ribozymes.Cold Spring Harbor perspectives in biology · 2010Review
- Intronic hammerhead ribozymes are ultraconserved in the human genome.EMBO reports · 2010Article
- Hammerhead ribozymes: true metal or nucleobase catalysis? Where is the catalytic power from?Molecules (Basel, Switzerland) · 2010Article
- Capturing hammerhead ribozyme structures in action by modulating general base catalysis.PLoS biology · 2008Article
- Multiple pattern matching: a Markov chain approach.Journal of mathematical biology · 2008Article
- Ribozymes, riboswitches and beyond: regulation of gene expression without proteins.Nature reviews. Genetics · 2007Review
- Characterization of a native hammerhead ribozyme derived from schistosomes.RNA (New York, N.Y.) · 2005Article
- Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hammerhead ribozymes previously were found in satellite RNAs from plant viroids and in repetitive DNA from certain species of newts and schistosomes. To determine if this catalytic RNA motif has a wider distribution, we decided to scrutinize the GenBank database for RNAs that contain hammerhead or hammerhead-like motifs. The search shows a widespread distribution of this kind of RNA motif in different sequences suggesting that they might have a more general role in RNA biology. The frequency of the hammerhead motif is half of that expected from a random distribution, but this fact comes from the low CpG representation in vertebrate sequences and the bias of the GenBank for those sequences. Intriguing motifs include those found in several families of repetitive sequences, in the satellite RNA from the carrot red leaf luteovirus, in plant viruses like the spinach latent virus and the elm mottle virus, in animal viruses like the hepatitis E virus and the caprine encephalitis virus, and in mRNAs such as those coding for cytochrome P450 oxidoreductase in the rat and the hamster.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.