ArticleThe EMBO journal2000
Role of ribosome recycling factor (RRF) in translational coupling.
Article in The EMBO journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 69 citations in OpenAlex.
- Genome-wide comparative analysis reveals distinct evolutionary patterns of overlapping genes in prokaryotes and eukaryotes.Heredity · 2026Article
- Translational coupling of neighboring genes in prokaryotes.Journal of bacteriology · 2025Review
- Kinetics of programmed and spontaneous ribosome sliding along the mRNA.Nucleic acids research · 2024Article
- Phenotypic and genetic insights into efflux pump mechanism inFrontiers in microbiology · 2023Article
- Role of ribosome recycling factor in natural termination and translational coupling as a ribosome releasing factor.PloS one · 2023Article
- Article
- Translational coupling via termination-reinitiation in archaea and bacteria.Nature communications · 2019Article
- Article
- Detoxifying Escherichia coli for endotoxin-free production of recombinant proteins.Microbial cell factories · 2015Article
- Overlapping genes: a new strategy of thermophilic stress tolerance in prokaryotes.Extremophiles : life under extreme conditions · 2015Article
- Phylogeny Inference of Closely Related Bacterial Genomes: Combining the Features of Both Overlapping Genes and Collinear Genomic Regions.Evolutionary bioinformatics online · 2015Article
- The fatty acid signaling molecule cis-2-decenoic acid increases metabolic activity and reverts persister cells to an antimicrobial-susceptible state.Applied and environmental microbiology · 2014Article
- Overlapping genes: a window on gene evolvability.BMC genomics · 2014Article
- Possible steps of complete disassembly of post-termination complex by yeast eEF3 deduced from inhibition by translocation inhibitors.Nucleic acids research · 2013Article
- The downstream atpE cistron is efficiently translated via its own cis-element in partially overlapping atpB-atpE dicistronic mRNAs in chloroplasts.Nucleic acids research · 2011Article
- Viral subversion of the host protein synthesis machinery.Nature reviews. Microbiology · 2011Review
- Translational independence between overlapping genes for a restriction endonuclease and its transcriptional regulator.BMC molecular biology · 2010Article
- PairWise Neighbours database: overlaps and spacers among prokaryote genomes.BMC genomics · 2009Article
- Direct expression of antimicrobial peptides in an intact form by a translationally coupled two-cistron expression system.Applied and environmental microbiology · 2009Article
- Termination codon-dependent translation of partially overlapping ndhC-ndhK transcripts in chloroplasts.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNA phage GA coat and lysis protein expression are translationally coupled through an overlapping termination and initiation codon UAAUG. Essential for this coupling are the proximity of the termination codon of the upstream coat gene to the initiation codon of the lysis gene (either a <3 nucleotide separation or physical closeness through a possible hairpin structure) but not the Shine-Dalgarno sequence. This suggests that the ribosomes completing the coat gene translation are exclusively responsible for translation of the lysis gene. Inactivation of ribosome recycling factor (RRF), which normally releases ribosomes at the termination codon, did not influence the expression of the reporter gene fused to the lysis gene. This suggests the possibility that RRF may not release ribosomes from the junction UAAUG. However, RRF is essential for correct ribosomal recognition of the AUG codon as the initiation site for the lysis gene.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.