ArticleThe EMBO journal2000
RNA-dependent cytoplasmic anchoring of a transcription factor subunit during Xenopus development.
Article in The EMBO journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- Regulated dicing of pre-mir-144 via reshaping of its terminal loop.Nucleic acids research · 2022Article
- Control of zygotic genome activation in Xenopus.Current topics in developmental biology · 2021Review
- The RNA binding complexes NF45-NF90 and NF45-NF110 associate dynamically with the c-fos gene and function as transcriptional coactivators.The Journal of biological chemistry · 2015Article
- Evidence for multiple, distinct ADAR-containing complexes in Xenopus laevis.RNA (New York, N.Y.) · 2015Article
- Review
- NF90 in posttranscriptional gene regulation and microRNA biogenesis.International journal of molecular sciences · 2013Review
- Phosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase PKR constitutes a novel mechanism of translational regulation and cellular defense.Genes & development · 2010Article
- Nuclear factor 45 (NF45) is a regulatory subunit of complexes with NF90/110 involved in mitotic control.Molecular and cellular biology · 2008Article
- NFAR-1 and -2 modulate translation and are required for efficient host defense.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Characterization of Staufen 1 ribonucleoprotein complexes.The Biochemical journal · 2004Article
- RNA binding and intramolecular interactions modulate the regulation of gene expression by nuclear factor 110.RNA (New York, N.Y.) · 2003Article
- Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteins.The Journal of cell biology · 2002Article
- The RNA binding protein nuclear factor 90 functions as both a positive and negative regulator of gene expression in mammalian cells.Molecular and cellular biology · 2002Article
- Thrombin induces the release of the Y-box protein dbpB from mRNA: a mechanism of transcriptional activation.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
The CCAAT box transcription factor (CBTF) is a multimeric transcription factor that activates expression of the haematopoietic regulatory factor, GATA-2. The 122 kDa subunit of this complex, CBTF(122), is cytoplasmic in fertilized Xenopus eggs and subsequently translocates to the nucleus prior to activation of zygotic GATA-2 transcription at gastrulation. Here we present data suggesting both a role for CBTF(122) prior to its nuclear translocation and the mechanism that retains it in the cytoplasm before the midblastula transition (MBT). CBTF(122) and its variant CBTF(98) are associated with translationally quiescent mRNP complexes. We show that CBTF(122) RNA binding activity is both necessary and sufficient for its cytoplasmic retention during early development. The introduction of an additional nuclear localization signal to CBTF(122) is insufficient to overcome this retention, suggesting that RNA binding acts as a cytoplasmic anchor for CBTF(122). Destruction of endogenous RNA by microinjection of RNase promotes premature nuclear translocation of CBTF(122). Thus, the nuclear translocation of CBTF(122) at the MBT is likely to be coupled to the degradation of maternal mRNA that occurs at that stage.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.