ArticleGenes & development2000
Long palindromes formed in Streptomyces by nonrecombinational intra-strand annealing.
Article in Genes & development, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Double-strand breaks induce inverted duplication chromosome rearrangements by a DNA polymerase δ-dependent mechanism.Nature communications · 2023Article
- Creating functional chromosome fusions in yeast with CRISPR-Cas9.Nature protocols · 2019Article
- Large inverted duplications in the human genome form via a fold-back mechanism.PLoS genetics · 2014Article
- E. coli SbcCD and RecA control chromosomal rearrangement induced by an interrupted palindrome.Molecular cell · 2010Article
- The actinomycin biosynthetic gene cluster of Streptomyces chrysomallus: a genetic hall of mirrors for synthesis of a molecule with mirror symmetry.Journal of bacteriology · 2010Article
- Sgs1 RecQ helicase inhibits survival of Saccharomyces cerevisiae cells lacking telomerase and homologous recombination.The Journal of biological chemistry · 2008Article
- Unusually long palindromes are abundant in mitochondrial control regions of insects and nematodes.PloS one · 2006Article
- A mechanism of palindromic gene amplification in Saccharomyces cerevisiae.Genes & development · 2005Article
- Telomerase- and recombination-independent immortalization of budding yeast.Genes & development · 2004Article
- Circularized chromosome with a large palindromic structure in Streptomyces griseus mutants.Journal of bacteriology · 2004Article
- Recruitment of terminal protein to the ends of Streptomyces linear plasmids and chromosomes by a novel telomere-binding protein essential for linear DNA replication.Genes & development · 2003Article
- Formation of large palindromic DNA by homologous recombination of short inverted repeat sequences in Saccharomyces cerevisiae.Genetics · 2002Article
- Inverted repeats as genetic elements for promoting DNA inverted duplication: implications in gene amplification.Nucleic acids research · 2001Article
- Terminal proteins essential for the replication of linear plasmids and chromosomes in Streptomyces.Genes & development · 2001Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Long inverted repeats (palindromes) are ubiquitous among prokaryotic and eukaryotic genomes. Earlier work has implicated both DNA breaks and short inverted repeats (IRs) in the formation of long palindromes in yeast and Tetrahymena by a proposed mechanism of intramolecular recombination. Here we report that long-palindromic linear plasmids are formed in Streptomyces following double strand DNA breakage by a nonrecombinational intra-strand annealing process that also involves IRs. By modification of palindrome-generating linear plasmids and development of a novel procedure that enables the sequencing of palindrome junctions, we show that long-palindrome formation occurs by unimolecular intra-strand annealing of IRs followed by 3' extension of the resulting DNA fold-back. The consequent hairpin structures serve as templates for synthesis of duplex linear plasmids containing long palindromes. We suggest that this model for long-palindrome formation in Streptomyces may represent a generally applicable mechanism for generating DNA palindromes.
Indexed as
Identifiers
10898793PMC316786W1924132532What OpenQuestion holds
Registered trials
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