ArticleGenes & development2000
Drosophila double parked: a conserved, essential replication protein that colocalizes with the origin recognition complex and links DNA replication with mitosis and the down-regulation of S phase transcripts.
Article in Genes & development, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
81 citing papers in PubMed, 188 citations in OpenAlex.
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- Loss-of-function of zebrafishJournal of Zhejiang University. Science. B · 2023Article
- Explainable multi-task learning improves the parallel estimation of polygenic risk scores for many diseases through shared genetic basis.PLoS computational biology · 2023Article
- An interplay between cellular growth and atypical fusion defines morphogenesis of a modular glial niche in Drosophila.Nature communications · 2022Article
- Noncanonical function of Capicua as a growth termination signal inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Replication initiation: Implications in genome integrity.DNA repair · 2021Review
- Deep neural network improves the estimation of polygenic risk scores for breast cancer.Journal of human genetics · 2021Article
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- Tissue-Specific DNA Replication Defects inGenetics · 2020Article
- Snail synchronizes endocycling in a TOR-dependent manner to coordinate entry and escape from endoreplication pausing during the Drosophila critical weight checkpoint.PLoS biology · 2020Article
- Nuclear Scaling Is Coordinated among Individual Nuclei in Multinucleated Muscle Fibers.Developmental cell · 2019Article
- Human NOC3 is essential for DNA replication licensing in human cells.Cell cycle (Georgetown, Tex.) · 2019Article
- Cdt1 variants reveal unanticipated aspects of interactions with cyclin/CDK and MCM important for normal genome replication.Molecular biology of the cell · 2018Article
- Rapid DNA Synthesis During EarlyGenetics · 2017Article
- DNA Replication Control DuringGenetics · 2017Review
- Initiation of Drosophila chorion gene amplification requires Claspin and mus101, whereas Claspin, but not mus101, plays a major role during elongation.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Article
- Two Geminin homologs regulate DNA replication in silkworm, Bombyx mori.Cell cycle (Georgetown, Tex.) · 2017Article
- Mechanisms and regulation of DNA replication initiation in eukaryotes.Critical reviews in biochemistry and molecular biology · 2017Review
- Regulation and Function of Cdt1; A Key Factor in Cell Proliferation and Genome Stability.Genes · 2016Review
- The Histone Variant H3.3 Is Enriched at Drosophila Amplicon Origins but Does Not Mark Them for Activation.G3 (Bethesda, Md.) · 2016Article
21 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We identified a Drosophila gene, double parked (dup), that is essential for DNA replication and belongs to a new family of replication proteins conserved from Schizosaccharomyces pombe to humans. Strong mutations in dup cause embryonic lethality, preceded by a failure to undergo S phase during the postblastoderm divisions. dup is required also for DNA replication in the adult ovary, establishing that dup is needed for DNA replication at multiple stages of development. Strikingly, DUP protein colocalizes with the origin recognition complex to specific sites in the ovarian follicle cells. This suggests that DUP plays a direct role in DNA replication. The dup transcript is cell cycle regulated and is under the control of E2F and Cyclin E. Interestingly, dup mutant embryos fail both to downregulate S phase genes and to engage a checkpoint preventing mitosis until completion of S phase. This could be either because these events depend on progression of S phase beyond the point blocked in the dup mutants or because DUP is needed directly for these feedback mechanisms.
Indexed as
Identifiers
10898791PMC316778W2145535073What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.