Evidence map›Paper›PMID 10898703›Full record

ArticleAntimicrobial agents and chemotherapy2000

Biochemical-genetic characterization and distribution of OXA-22, a chromosomal and inducible class D beta-lactamase from Ralstonia (Pseudomonas) pickettii.

P Nordmann, L Poirel, M Kubina, A Casetta, T Naas

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Incidence, relevance and response for Ralsfonia respiratory infections.Clinical laboratory science : journal of the American Society for Medical Technology · 2010
    Pooled it
  2. Article
  3. Article
  4. Article
  5. NovelMicrobiology spectrum · 2024
    Article
  6. Genomic analysis ofFrontiers in microbiology · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Antimicrobial resistance and infection control · 2017
    Article
  11. Article
  12. Ralstonia spp.: emerging global opportunistic pathogens.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014
    Review
  13. Article
  14. Article
  15. Diversity, epidemiology, and genetics of class D beta-lactamases.Antimicrobial agents and chemotherapy · 2010
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

P NordmannService de Bactériologie-Virologie, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine Paris-Sud, 94275 Le Kremlin-Bicêtre, France. nordmann.patrice@bct.ap-hop-paris.fr
L Poirel
M Kubina
A Casetta
T Naas
Bicêtre Hospital · FRAssistance Publique – Hôpitaux de Paris · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

From genomic DNA of Ralstonia pickettii isolate PIC-1, a beta-lactamase gene was cloned that encodes the oxacillinase OXA-22. It differs from known oxacillinases, being most closely related to OXA-9 (38% amino acid identity). The hydrolytic spectrum of OXA-22 is limited mostly to benzylpenicillin, cloxacillin, and restricted-spectrum cephalosporins. OXA-22-like genes were identified as single chromosomal copies in five other R. pickettii clinical isolates. The expression of OXA-22-like beta-lactamases was inducible in R. pickettii.

Indexed as

Amino Acid SequenceAnti-Bacterial Agentsbeta-Lactamasesbeta-Lactam Resistancebeta-LactamsChromosomes, BacterialCloning, MolecularEnzyme InductionHumansMicrobial Sensitivity TestsMolecular Sequence DataPseudomonasSequence Homology, Amino AcidAnti-Bacterial Agentsbeta-lactamase OXA-22beta-Lactamasesbeta-Lactams

Identifiers

PMID10898703
PMCPMC90041
OpenAlexW2030338103

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.