ArticleMolecular pathology : MP2000
Genetic relation of lobular carcinoma in situ, ductal carcinoma in situ, and associated invasive carcinoma of the breast.
Article in Molecular pathology : MP, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 121 citations in OpenAlex.
- Quantitative expression of MMPs 2, 9, 14, and collagen IV in LCIS and paired normal breast tissue.Scientific reports · 2019Article
- The PPARγ agonist efatutazone delays invasive progression and induces differentiation of ductal carcinoma in situ.Breast cancer research and treatment · 2018Article
- Mixed ductal-lobular carcinomas: evidence for progression from ductal to lobular morphology.The Journal of pathology · 2018Article
- Lobular Carcinoma In Situ.Surgical pathology clinics · 2018Review
- Incidental Findings in Reduction Mammoplasty Specimens in Patients with No Prior History of Breast Cancer. An Analysis of 783 Specimens.Pathology oncology research : POR · 2018Article
- Multicolor immunofluorescence reveals that p63- and/or K5-positive progenitor cells contribute to normal breast epithelium and usual ductal hyperplasia but not to low-grade intraepithelial neoplasia of the breast.Virchows Archiv : an international journal of pathology · 2017Observational
- Hormone Replacement Therapy, Likely Neither Angel Nor Demon.PloS one · 2015Article
- Analysis of gene copy number alterations by multiplex ligation-dependent probe amplification in columnar cell lesions of the breast.Cellular oncology (Dordrecht, Netherlands) · 2014Article
- Next-generation sequencing: a powerful tool for the discovery of molecular markers in breast ductal carcinoma in situ.Expert review of molecular diagnostics · 2013Review
- Coexisting ductal carcinoma in situ independently predicts lower tumor aggressiveness in node-positive luminal breast cancer.Medical oncology (Northwood, London, England) · 2012Article
- Molecular differences between ductal carcinoma in situ and adjacent invasive breast carcinoma: a multiplex ligation-dependent probe amplification study.Cellular oncology (Dordrecht, Netherlands) · 2011Article
- The changing role of pathology in breast cancer diagnosis and treatment.Pathobiology : journal of immunopathology, molecular and cellular biology · 2011Review
- NUCKS overexpression in breast cancer.Cancer cell international · 2009Article
- Breast cancer subtypes and response to docetaxel in node-positive breast cancer: use of an immunohistochemical definition in the BCIRG 001 trial.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2009Article
- Breast cancer precursors: lessons learned from molecular genetics.Journal of molecular medicine (Berlin, Germany) · 2009Article
- Immunohistochemical and proteomic evaluation of nuclear ubiquitous casein and cyclin-dependent kinases substrate in invasive ductal carcinoma of the breast.Journal of biomedicine & biotechnology · 2009Article
- The assessment of angiogenesis and fibroblastic stromagenesis in hyperplastic and pre-invasive breast lesions.BMC cancer · 2008Article
- Non-operative breast pathology: lobular neoplasia.Journal of clinical pathology · 2007Review
- Assessing the significance of conserved genomic aberrations using high resolution genomic microarrays.PLoS genetics · 2007Article
- Genomics and premalignant breast lesions: clues to the development and progression of lobular breast cancer.Breast cancer research : BCR · 2007Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe mutual relation of lobular carcinoma in situ (LCIS) and ductal carcinoma in situ (DCIS) of the breast, as accepted precursor lesions of invasive breast cancer, is controversial. Because they display genetic heterogeneity, it is not clear how genetically advanced these entities are and what causes the transition to an invasive carcinoma.
methodsSix cases of LCIS, four of them with associated lobular invasive carcinoma, four cases of intermediately differentiated DCIS with an associated invasive lobular carcinoma, and nine cases of intermediately and poorly differentiated DCIS with associated ductal invasive carcinoma were investigated by means of comparative genomic hybridisation (CGH) after microdissection and immunohistochemical staining of E-cadherin.
resultsLCIS was characterised by a low average rate of copy number changes, no evidence of amplifications, and a high rate of gains and losses of chromosomal material at 1q and 16q, respectively. A high degree of genetic homology with well differentiated DCIS was obvious, as reported previously. The cases of intermediately differentiated DCIS with associated lobular invasive components and lobular differentiation revealed striking homologies, and a significant difference of E-cadherin expression. The comparison of preinvasive and invasive breast lesions, irrespective of differentiation within the same patient, revealed no specific alteration that might be associated with invasion. Genetic alterations seen in invasive carcinoma were not necessarily seen in the adjacent precursor lesions.
conclusionsThese results provide strong evidence that invasive breast cancer is a disease with multiple cytogenetic subclones already present in preinvasive lesions. Moreover, specific CGH alterations associated with invasion were not observed. Furthermore, the close genetic association between well differentiated and a subgroup of intermediately differentiated DCIS and LCIS led to the hypothesis that LCIS and a subgroup of DCIS are different phenotypic forms of a common genotype.
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