ArticleGut2000
The role of polyamines in gastric mucus synthesis inhibited by cigarette smoke or its extract.
Article in Gut, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 43 citations in OpenAlex.
- Oral dryness related symptoms in radiation-treated head and neck cancer patients: a pilot study of oral microbiome composition and function.BMC microbiology · 2026Article
- Agmatine Administration Effects on Equine Gastric Ulceration and Lameness.Journal of clinical medicine · 2022Article
- Bioconjugation strategy for cell surface labelling with gold nanostructures designed for highly localized pH measurement.Nature communications · 2018Article
- Case-case comparison of smoking and alcohol risk associations with Epstein-Barr virus-positive gastric cancer.International journal of cancer · 2014Article
- Intrarectal administration of mCRAMP-encoding plasmid reverses exacerbated colitis in Cnlp(-/-) mice.Gene therapy · 2013Article
- Antiulcer activity of Amlapitta Mishran suspension in rats: A pilot study.Ancient science of life · 2012Article
- Effect of smoking on failure of H. pylori therapy and gastric histology in a high gastric cancer risk area of Colombia.Acta gastroenterologica Latinoamericana · 2007Article
- Smoking-gene interaction and disease development: relevance to pancreatic cancer and atherosclerosis.World journal of surgery · 2005Review
- Smoking and the pathogenesis of gastroduodenal ulcer--recent mechanistic update.Molecular and cellular biochemistry · 2003Review
- Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis.The Journal of clinical investigation · 2003Article
- Simultaneous determination of different polyamines and their mono-acetylated derivatives in gastric tissue by HPLC with post-column derivatization.Scientia pharmaceuticaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCigarette smoking was shown to delay gastric ulcer healing and reduce synthesis of mucus, which is important for gastric ulcer protection and healing. Polyamines are important in these processes.
aimsTo study the effects of cigarette smoking on the synthesis of mucus and to investigate if such an effect is acting by interference with the polyamine pathway.
methodsGastric mucosal ornithine decarboxylase activity, mucous secreting layer thickness, and ulcer size were determined after different concentrations of cigarette smoke exposure (0, 2, or 4%) in intact animals and animals with ulcers. Synthesis of mucus and ornithine decarboxylase activity and mRNA expression were also assessed in cigarette smoke extract treated MKN-28 cells.
resultsExposure to cigarette smoke significantly reduced the thickness of the mucous secreting layer and gastric mucosal ornithine decarboxylase activity in animals with or without ulcers. Spermidine not only reversed inhibition of mucus synthesis in both intact and ulcer bearing animals but also reversed the delay in ulcer healing. Cigarette smoke extract significantly reduced mucus synthesis and ornithine decarboxylase activity but not its mRNA expression in MKN-28 cells. The reduction in mucus synthesis was restored by spermidine.
conclusionsCigarette smoke and its extract repress mucus synthesis in vivo and in vitro, respectively. Reduction of ornithine decarboxylase activity in gastric mucosa is closely associated with this effect.
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