ArticleThe Journal of physiology2000
A regulator of G protein signalling (RGS) protein confers agonist-dependent relaxation gating to a G protein-gated K+ channel.
Article in The Journal of physiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 47 citations in OpenAlex.
- Differential voltage-dependent modulation of the ACh-gated K+ current by adenosine and acetylcholine.PloS one · 2022Article
- Structural determinants at the M2 muscarinic receptor modulate the RGS4-GIRK response to pilocarpine by impairment of the receptor voltage sensitivity.Scientific reports · 2017Article
- RGS4 regulates partial agonism of the M2 muscarinic receptor-activated K+ currents.The Journal of physiology · 2014Article
- RGS Proteins in Heart: Brakes on the Vagus.Frontiers in physiology · 2012Article
- Relaxation gating of the acetylcholine-activated inward rectifier K+ current is mediated by intrinsic voltage sensitivity of the muscarinic receptor.The Journal of physiology · 2011Article
- HL-1 cells express an inwardly rectifying K+ current activated via muscarinic receptors comparable to that in mouse atrial myocytes.Pflugers Archiv : European journal of physiology · 2010Article
- Cardiac strong inward rectifier potassium channels.Journal of molecular and cellular cardiology · 2010Review
- Phosphatidylinositol 3,4,5-trisphosphate and Ca2+/calmodulin competitively bind to the regulators of G-protein-signalling (RGS) domain of RGS4 and reciprocally regulate its action.The Biochemical journal · 2005Article
- Cell signal control of the G protein-gated potassium channel and its subcellular localization.The Journal of physiology · 2004Review
- Electrophysiological evidence for a gradient of G protein-gated K+ current in adult mouse atria.British journal of pharmacology · 2003Article
- RGS3 mediates a calcium-dependent termination of G protein signaling in sensory neurons.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Agonist unbinding from receptor dictates the nature of deactivation kinetics of G protein-gated K+ channels.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Graded contribution of the Gbeta gamma binding domains to GIRK channel activation.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- PIP3 inhibition of RGS protein and its reversal by Ca2+/calmodulin mediate voltage-dependent control of the G protein cycle in a cardiac K+ channel.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Differential regulation of G protein-gated inwardly rectifying K(+) channel kinetics by distinct domains of RGS8.The Journal of physiology · 2001Article
- Interaction between the RGS domain of RGS4 with G protein alpha subunits mediates the voltage-dependent relaxation of the G protein-gated potassium channel.The Journal of physiology · 2001Article
- The role of G proteins in assembly and function of Kir3 inwardly rectifying potassium channels.Channels (Austin, Tex.)Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The effects of RGS4 on the voltage-dependent relaxation of G protein-gated K+ (KG) channels were examined by heterologous expression in Xenopus oocytes. 2. While the relaxation kinetics was unaffected by the acetylcholine concentration ([ACh]) in the absence of RGS4, it became dependent on [ACh] when RGS4 was co-expressed. 3. Kinetic analyses indicated that RGS4 confers to the KG channel a voltage-independent inhibitory gating mechanism, which was attenuated by ACh in a concentration-dependent fashion. 4. In vitro biochemical studies showed that RGS4 could bind to the protein complex containing KG channel subunits. 5. Since the native cardiac KG channel exhibited similar agonist-dependent relaxation kinetics to that mediated by RGS4, it is suggested that KG channel gating is a novel physiological target of RGS protein-mediated regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.