ArticleThe Journal of cell biology2000
Mitotic transcription repression in vivo in the absence of nucleosomal chromatin condensation.
Article in The Journal of cell biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 92 citations in OpenAlex.
- MYC phase separation selectively modulates the transcriptome.Nature structural & molecular biology · 2024Article
- Phase separation of YAP-MAML2 differentially regulates the transcriptome.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Characterization of factors that underlie transcriptional silencing in C. elegans oocytes.PLoS genetics · 2023Article
- SARS-CoV-2 3CLpro whole human proteome cleavage prediction and enrichment/depletion analysis.Computational biology and chemistry · 2022Article
- The Trithorax group protein ASH1 requires a combination of BAH domain and AT hooks, but not the SET domain, for mitotic chromatin binding and survival.Chromosoma · 2021Article
- A theoretical model of Polycomb/Trithorax action unites stable epigenetic memory and dynamic regulation.Nature communications · 2020Article
- Nuclear localization signal region in nuclear receptor PXR governs the receptor association with mitotic chromatin.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2018Article
- Article
- Slow Chromatin Dynamics Allow Polycomb Target Genes to Filter Fluctuations in Transcription Factor Activity.Cell systems · 2017Article
- Cycling through developmental decisions: how cell cycle dynamics control pluripotency, differentiation and reprogramming.Development (Cambridge, England) · 2016Review
- A role for mitotic bookmarking of SOX2 in pluripotency and differentiation.Genes & development · 2016Article
- IFI16 restricts HSV-1 replication by accumulating on the hsv-1 genome, repressing HSV-1 gene expression, and directly or indirectly modulating histone modifications.PLoS pathogens · 2014Article
- What are memories made of? How Polycomb and Trithorax proteins mediate epigenetic memory.Nature reviews. Molecular cell biology · 2014Review
- Targeting deregulated epigenetic control in cancer.Journal of cellular physiology · 2013Review
- Class I HDAC imaging using [ (3)H]CI-994 autoradiography.Epigenetics · 2013Article
- Bookmarking by specific and nonspecific binding of FoxA1 pioneer factor to mitotic chromosomes.Genes & development · 2013Article
- Correlative fluorescence and EFTEM imaging of the organized components of the mammalian nucleus.Methods in molecular biology (Clifton, N.J.) · 2013Article
- Bookmarking the genome: maintenance of epigenetic information.The Journal of biological chemistry · 2011Review
- MT7, a novel compound from a combinatorial library, arrests mitosis via inhibiting the polymerization of microtubules.Investigational new drugs · 2010Article
- Mitotic bookmarking of genes: a novel dimension to epigenetic control.Nature reviews. Genetics · 2010Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
All nuclear RNA synthesis is repressed during the mitotic phase of the cell cycle. In addition, RNA polymerase II (RNAP II), nascent RNA and many transcription factors disengage from DNA during mitosis. It has been proposed that mitotic transcription repression and disengagement of factors are due to either mitotic chromatin condensation or biochemical modifications to the transcription machinery. In this study, we investigate the requirement for chromatin condensation in establishing mitotic transcription repression and factor loss, by analyzing transcription and RNAP II localization in mitotic cells infected with herpes simplex virus type 1. We find that virus-infected cells enter mitosis and that mitotic viral DNA is maintained in a nucleosome-free and noncondensed state. Our data show that RNAP II transcription is repressed on cellular genes that are condensed into mitotic chromosomes and on viral genes that remain nucleosome free and noncondensed. Although RNAP II may interact indirectly with viral DNA during mitosis, it remains transcriptionally unengaged. This study demonstrates that mitotic repression of transcription and loss of transcription factors from mitotic DNA can occur independently of nucleosomal chromatin condensation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.