ArticleMolecular and cellular biology2000
Architecture of the replication fork stalled at the 3' end of yeast ribosomal genes.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 64 citations in OpenAlex.
- Genome-wide analysis of DNA replication and DNA double-strand breaks using TrAEL-seq.PLoS biology · 2021Article
- Rad53-Mediated Regulation of Rrm3 and Pif1 DNA Helicases Contributes to Prevention of Aberrant Fork Transitions under Replication Stress.Cell reports · 2015Article
- The DNA-Binding Domain of S. pombe Mrc1 (Claspin) Acts to Enhance Stalling at Replication Barriers.PloS one · 2015Article
- Recombination and replication.Cold Spring Harbor perspectives in biology · 2014Review
- G4 motifs affect origin positioning and efficiency in two vertebrate replicators.The EMBO journal · 2014Article
- RNase-dependent discontinuities associated with the crossovers of spontaneously formed joint DNA molecules in Physarum polycephalum.Chromosoma · 2010Article
- Replication termination at eukaryotic chromosomes is mediated by Top2 and occurs at genomic loci containing pausing elements.Molecular cell · 2010Article
- Replication fork reversal and the maintenance of genome stability.Nucleic acids research · 2009Review
- The unnamed complex: what do we know about Smc5-Smc6?Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2009Review
- ATR: an essential regulator of genome integrity.Nature reviews. Molecular cell biology · 2008Review
- Regression supports two mechanisms of fork processing in phage T4.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- Replication fork barriers: pausing for a break or stalling for time?EMBO reports · 2007Review
- Replication fork progression is impaired by transcription in hyperrecombinant yeast cells lacking a functional THO complex.Molecular and cellular biology · 2006Article
- Rad22Rad52-dependent repair of ribosomal DNA repeats cleaved by Slx1-Slx4 endonuclease.Molecular biology of the cell · 2006Article
- Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork.Genes & development · 2005Article
- Saccharomyces cerevisiae Rrm3p DNA helicase promotes genome integrity by preventing replication fork stalling: viability of rrm3 cells requires the intra-S-phase checkpoint and fork restart activities.Molecular and cellular biology · 2004Article
- RNase-sensitive DNA modification(s) initiates S. pombe mating-type switching.Genes & development · 2004Article
- Slx1-Slx4 are subunits of a structure-specific endonuclease that maintains ribosomal DNA in fission yeast.Molecular biology of the cell · 2004Article
- Rad52-independent accumulation of joint circular minichromosomes during S phase in Saccharomyces cerevisiae.Molecular and cellular biology · 2003Article
- Association of the RENT complex with nontranscribed and coding regions of rDNA and a regional requirement for the replication fork block protein Fob1 in rDNA silencing.Genes & development · 2003Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Every unit of the rRNA gene cluster of Saccharomyces cerevisiae contains a unique site, termed the replication fork barrier (RFB), where progressing replication forks are stalled in a polar manner. In this work, we determined the positions of the nascent strands at the RFB at nucleotide resolution. Within an HpaI-HindIII fragment essential for the RFB, a major and two closely spaced minor arrest sites were found. In the majority of molecules, the stalled lagging strand was completely processed and the discontinuously synthesized nascent lagging strand was extended three bases farther than the continuously synthesized leading strand. A model explaining these findings is presented. Our analysis included for the first time the use of T4 endonuclease VII, an enzyme recognizing branched DNA molecules. This enzyme cleaved predominantly in the newly synthesized homologous arms, thereby specifically releasing the leading arm.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.