ArticleMolecular and cellular biology2000
Species-specific elements in the large T-antigen J domain are required for cellular transformation and DNA replication by simian virus 40.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 79 citations in OpenAlex.
- Extracellular chaperone networks and the export of J-domain proteins.The Journal of biological chemistry · 2023Review
- Merkel cell polyomavirus T-antigens regulateiScience · 2021Article
- Detection of JC Polyomavirus tumor antigen in gastric carcinoma: a report from Iran.Iranian journal of microbiology · 2018Article
- Copy Number Heterogeneity of JC Virus Standards.Journal of clinical microbiology · 2017Article
- Immune response to JC virus T antigen in patients with and without colorectal neoplasia.Gut microbes · 2014Article
- The HSP70 modulator MAL3-101 inhibits Merkel cell carcinoma.PloS one · 2014Article
- Polycyclic aromatic hydrocarbons-induced ROS accumulation enhances mutagenic potential of T-antigen from human polyomavirus JC.Journal of cellular physiology · 2013Article
- T antigen transformation reveals Tp53/RB-dependent route to PLAC1 transcription activation in primary fibroblasts.Oncogenesis · 2013Article
- Article
- Functional domain analysis of the Mycoplasma pneumoniae co-chaperone TopJ.Molecular microbiology · 2010Article
- Heat shock protein 70 (hsp70) as an emerging drug target.Journal of medicinal chemistry · 2010Review
- IGF-IR-dependent expression of Survivin is required for T-antigen-mediated protection from apoptosis and proliferation of neural progenitors.Cell death and differentiation · 2010Article
- Article
- Multi-faceted role of HSP40 in cancer.Clinical & experimental metastasis · 2009Review
- Association of simian virus 40 vp1 with 70-kilodalton heat shock proteins and viral tumor antigens.Journal of virology · 2009Article
- Enterocyte proliferation and intestinal hyperplasia induced by simian virus 40 T antigen require a functional J domain.Journal of virology · 2007Article
- High JC virus load in gastric cancer and adjacent non-cancerous mucosa.Cancer science · 2007Article
- Cytosolic and ER J-domains of mammalian and parasitic origin can functionally interact with DnaK.The international journal of biochemistry & cell biology · 2007Article
- Interaction of retinoblastoma protein family members with large T-antigen of primate polyomaviruses.Oncogene · 2006Review
- Role of the interaction between large T antigen and Rb family members in the oncogenicity of JC virus.Oncogene · 2006Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The J domain of simian virus 40 (SV40) large T antigen is required for efficient DNA replication and transformation. Despite previous reports demonstrating the promiscuity of J domains in heterologous systems, results presented here show the requirement for specific J-domain sequences in SV40 large-T-antigen-mediated activities. In particular, chimeric-T-antigen constructs in which the SV40 T-antigen J domain was replaced with that from the yeast Ydj1p or Escherichia coli DnaJ proteins failed to replicate in BSC40 cells and did not transform REF52 cells. However, T antigen containing the JC virus J domain was functional in these assays, although it was less efficient than the wild type. The inability of some large-T-antigen chimeras to promote DNA replication and elicit cellular transformation was not due to a failure to interact with hsc70, since a nonfunctional chimera, containing the DnaJ J domain, bound hsc70. However, this nonfunctional chimeric T antigen was reduced in its ability to stimulate hsc70 ATPase activity and unable to liberate E2F from p130, indicating that transcriptional activation of factors required for cell growth and DNA replication may be compromised. Our data suggest that the T-antigen J domain harbors species-specific elements required for viral activities in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.